Relationship of Bcl-2 expression with MMP2 and MMP9 expression in hepatocellular carcinoma and their correlation with recurrence, metastasis, and prognosis

Tao Sun, Baocun Sun, Xiulan Zhao, Nan Zhao, Qiang Gu, Na Che, Xueyi Dong, Jiadong Chi

Research output: Contribution to journalArticle

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Abstract

Objective: To determine the correlation of the expression of the anti-apoptotic protein Bcl-2 with the expression of matrix metalloproteinases MMP-2 and MMP-9 in human hepatocellular carcinoma, and their relationship with recurrence, metastasis, and prognosis. Methods: Paraffin-embedded tissue sections of 97 hepatocellular carcinoma cases were subjected to SP immunohistochemical staining. The nuclear expression of Bcl-2 as well as the expression of MMP-2 and MMP-9 were detected. A total of 49 cases had recurrence and metastasis, and the remaining 48 did not. Results: The nuclear expression of Bcl-2 was higher in cases with recurrence and/or metastasis (t = -2.488, P = 0.015). Similarly, MMP-2 and MMP-9 expression were higher in cases with recurrence and/or metastasis (Z = -2.623, P = 0.009; Z = -2.028, P = 0.043). The nuclear expression of Bcl-2 was correlated with the expression of MMP-9, but not with that of MMP-2. Patients with positive nuclear expression of Bcl-2 had shorter survival time, and the difference was significant. Conclusion: The nuclear expression of Bcl-2 was significantly correlated with metastasis and MMP-9 expression. Bcl-2 relocation into the nucleus may regulate metastasis-related proteins, which can be used as a clinical marker for evaluating recurrence, metastasis, and prognosis.

Original languageEnglish (US)
JournalChinese Journal of Clinical Oncology
Volume39
Issue number11
DOIs
StatePublished - Jul 15 2012

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Matrix Metalloproteinases
Hepatocellular Carcinoma
Neoplasm Metastasis
Recurrence
Apoptosis Regulatory Proteins
Matrix Metalloproteinase 2
Paraffin
Biomarkers
Staining and Labeling
Survival

Keywords

  • Bcl-2
  • MMP-2
  • MMP-9
  • Recurrence and metastasis

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Relationship of Bcl-2 expression with MMP2 and MMP9 expression in hepatocellular carcinoma and their correlation with recurrence, metastasis, and prognosis. / Sun, Tao; Sun, Baocun; Zhao, Xiulan; Zhao, Nan; Gu, Qiang; Che, Na; Dong, Xueyi; Chi, Jiadong.

In: Chinese Journal of Clinical Oncology, Vol. 39, No. 11, 15.07.2012.

Research output: Contribution to journalArticle

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title = "Relationship of Bcl-2 expression with MMP2 and MMP9 expression in hepatocellular carcinoma and their correlation with recurrence, metastasis, and prognosis",
abstract = "Objective: To determine the correlation of the expression of the anti-apoptotic protein Bcl-2 with the expression of matrix metalloproteinases MMP-2 and MMP-9 in human hepatocellular carcinoma, and their relationship with recurrence, metastasis, and prognosis. Methods: Paraffin-embedded tissue sections of 97 hepatocellular carcinoma cases were subjected to SP immunohistochemical staining. The nuclear expression of Bcl-2 as well as the expression of MMP-2 and MMP-9 were detected. A total of 49 cases had recurrence and metastasis, and the remaining 48 did not. Results: The nuclear expression of Bcl-2 was higher in cases with recurrence and/or metastasis (t = -2.488, P = 0.015). Similarly, MMP-2 and MMP-9 expression were higher in cases with recurrence and/or metastasis (Z = -2.623, P = 0.009; Z = -2.028, P = 0.043). The nuclear expression of Bcl-2 was correlated with the expression of MMP-9, but not with that of MMP-2. Patients with positive nuclear expression of Bcl-2 had shorter survival time, and the difference was significant. Conclusion: The nuclear expression of Bcl-2 was significantly correlated with metastasis and MMP-9 expression. Bcl-2 relocation into the nucleus may regulate metastasis-related proteins, which can be used as a clinical marker for evaluating recurrence, metastasis, and prognosis.",
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T1 - Relationship of Bcl-2 expression with MMP2 and MMP9 expression in hepatocellular carcinoma and their correlation with recurrence, metastasis, and prognosis

AU - Sun, Tao

AU - Sun, Baocun

AU - Zhao, Xiulan

AU - Zhao, Nan

AU - Gu, Qiang

AU - Che, Na

AU - Dong, Xueyi

AU - Chi, Jiadong

PY - 2012/7/15

Y1 - 2012/7/15

N2 - Objective: To determine the correlation of the expression of the anti-apoptotic protein Bcl-2 with the expression of matrix metalloproteinases MMP-2 and MMP-9 in human hepatocellular carcinoma, and their relationship with recurrence, metastasis, and prognosis. Methods: Paraffin-embedded tissue sections of 97 hepatocellular carcinoma cases were subjected to SP immunohistochemical staining. The nuclear expression of Bcl-2 as well as the expression of MMP-2 and MMP-9 were detected. A total of 49 cases had recurrence and metastasis, and the remaining 48 did not. Results: The nuclear expression of Bcl-2 was higher in cases with recurrence and/or metastasis (t = -2.488, P = 0.015). Similarly, MMP-2 and MMP-9 expression were higher in cases with recurrence and/or metastasis (Z = -2.623, P = 0.009; Z = -2.028, P = 0.043). The nuclear expression of Bcl-2 was correlated with the expression of MMP-9, but not with that of MMP-2. Patients with positive nuclear expression of Bcl-2 had shorter survival time, and the difference was significant. Conclusion: The nuclear expression of Bcl-2 was significantly correlated with metastasis and MMP-9 expression. Bcl-2 relocation into the nucleus may regulate metastasis-related proteins, which can be used as a clinical marker for evaluating recurrence, metastasis, and prognosis.

AB - Objective: To determine the correlation of the expression of the anti-apoptotic protein Bcl-2 with the expression of matrix metalloproteinases MMP-2 and MMP-9 in human hepatocellular carcinoma, and their relationship with recurrence, metastasis, and prognosis. Methods: Paraffin-embedded tissue sections of 97 hepatocellular carcinoma cases were subjected to SP immunohistochemical staining. The nuclear expression of Bcl-2 as well as the expression of MMP-2 and MMP-9 were detected. A total of 49 cases had recurrence and metastasis, and the remaining 48 did not. Results: The nuclear expression of Bcl-2 was higher in cases with recurrence and/or metastasis (t = -2.488, P = 0.015). Similarly, MMP-2 and MMP-9 expression were higher in cases with recurrence and/or metastasis (Z = -2.623, P = 0.009; Z = -2.028, P = 0.043). The nuclear expression of Bcl-2 was correlated with the expression of MMP-9, but not with that of MMP-2. Patients with positive nuclear expression of Bcl-2 had shorter survival time, and the difference was significant. Conclusion: The nuclear expression of Bcl-2 was significantly correlated with metastasis and MMP-9 expression. Bcl-2 relocation into the nucleus may regulate metastasis-related proteins, which can be used as a clinical marker for evaluating recurrence, metastasis, and prognosis.

KW - Bcl-2

KW - MMP-2

KW - MMP-9

KW - Recurrence and metastasis

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