Relaxin signaling in uterine fibroids

Zhen Li, Jennifer K. Burzawa, Anne Troung, Shu Feng, Irina U. Agoulnik, Xiaowen Tong, Matthew L. Anderson, Ertug Kovanci, Aleksandar Rajkovic, Alexander I. Agoulnik

Research output: Chapter in Book/Report/Conference proceedingConference contribution

7 Scopus citations

Abstract

Uterine fibroid is the most common tumor of female reproductive organs. The role of relaxin signaling in leiomyoma development was analyzed. We used 23 matched pairs of leiomyoma and normal myometrium samples to compare the expression of relaxin family peptide receptors RXFP1 and RXFP2, caveolin 1, desmin, and steroid receptors and their cofactors, NCOR1 and NCOR2. The expression of RXFP1, evaluated by quantitative reverse transcription-PCR, was downregulated in fibroid tissues. Relaxin or insulin-like peptide 3 treatment suppressed transforming growth factor β-induced phosphorylation of SMAD2 in rat leiomyoma ELT-3 cells in vitro, suggesting a possible involvement of relaxins in the etiology of leiomyoma.

Original languageEnglish (US)
Title of host publicationRelaxin and Related Peptides Fifth International Conference
PublisherBlackwell Publishing Inc.
Pages374-378
Number of pages5
ISBN (Print)9781573317214
DOIs
StatePublished - Apr 2009

Publication series

NameAnnals of the New York Academy of Sciences
Volume1160
ISSN (Print)0077-8923
ISSN (Electronic)1749-6632

Keywords

  • INSL3
  • Leiomyoma
  • Phospho-SMAD2
  • Relaxin
  • Transforming growth factor

ASJC Scopus subject areas

  • General Neuroscience
  • General Biochemistry, Genetics and Molecular Biology
  • History and Philosophy of Science

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