TY - GEN
T1 - Relaxin signaling in uterine fibroids
AU - Li, Zhen
AU - Burzawa, Jennifer K.
AU - Troung, Anne
AU - Feng, Shu
AU - Agoulnik, Irina U.
AU - Tong, Xiaowen
AU - Anderson, Matthew L.
AU - Kovanci, Ertug
AU - Rajkovic, Aleksandar
AU - Agoulnik, Alexander I.
PY - 2009/4
Y1 - 2009/4
N2 - Uterine fibroid is the most common tumor of female reproductive organs. The role of relaxin signaling in leiomyoma development was analyzed. We used 23 matched pairs of leiomyoma and normal myometrium samples to compare the expression of relaxin family peptide receptors RXFP1 and RXFP2, caveolin 1, desmin, and steroid receptors and their cofactors, NCOR1 and NCOR2. The expression of RXFP1, evaluated by quantitative reverse transcription-PCR, was downregulated in fibroid tissues. Relaxin or insulin-like peptide 3 treatment suppressed transforming growth factor β-induced phosphorylation of SMAD2 in rat leiomyoma ELT-3 cells in vitro, suggesting a possible involvement of relaxins in the etiology of leiomyoma.
AB - Uterine fibroid is the most common tumor of female reproductive organs. The role of relaxin signaling in leiomyoma development was analyzed. We used 23 matched pairs of leiomyoma and normal myometrium samples to compare the expression of relaxin family peptide receptors RXFP1 and RXFP2, caveolin 1, desmin, and steroid receptors and their cofactors, NCOR1 and NCOR2. The expression of RXFP1, evaluated by quantitative reverse transcription-PCR, was downregulated in fibroid tissues. Relaxin or insulin-like peptide 3 treatment suppressed transforming growth factor β-induced phosphorylation of SMAD2 in rat leiomyoma ELT-3 cells in vitro, suggesting a possible involvement of relaxins in the etiology of leiomyoma.
KW - INSL3
KW - Leiomyoma
KW - Phospho-SMAD2
KW - Relaxin
KW - Transforming growth factor
UR - http://www.scopus.com/inward/record.url?scp=64549108513&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=64549108513&partnerID=8YFLogxK
U2 - 10.1111/j.1749-6632.2008.03803.x
DO - 10.1111/j.1749-6632.2008.03803.x
M3 - Conference contribution
C2 - 19416222
AN - SCOPUS:64549108513
SN - 9781573317214
T3 - Annals of the New York Academy of Sciences
SP - 374
EP - 378
BT - Relaxin and Related Peptides Fifth International Conference
PB - Blackwell Publishing Inc.
ER -