Relaxin signaling in uterine fibroids

Zhen Li, Jennifer Kelly Burzawa, Anne Troung, Shu Feng, Irina U. Agoulnik, Xiaowen Tong, Matthew L. Anderson, Ertug Kovanci, Aleksandar Rajkovic, Alexander I. Agoulnik

Research output: Chapter in Book/Report/Conference proceedingConference contribution

7 Citations (Scopus)

Abstract

Uterine fibroid is the most common tumor of female reproductive organs. The role of relaxin signaling in leiomyoma development was analyzed. We used 23 matched pairs of leiomyoma and normal myometrium samples to compare the expression of relaxin family peptide receptors RXFP1 and RXFP2, caveolin 1, desmin, and steroid receptors and their cofactors, NCOR1 and NCOR2. The expression of RXFP1, evaluated by quantitative reverse transcription-PCR, was downregulated in fibroid tissues. Relaxin or insulin-like peptide 3 treatment suppressed transforming growth factor β-induced phosphorylation of SMAD2 in rat leiomyoma ELT-3 cells in vitro, suggesting a possible involvement of relaxins in the etiology of leiomyoma.

Original languageEnglish (US)
Title of host publicationRelaxin and Related Peptides Fifth International Conference
PublisherBlackwell Publishing Inc.
Pages374-378
Number of pages5
ISBN (Print)9781573317214
DOIs
StatePublished - Jan 1 2009

Publication series

NameAnnals of the New York Academy of Sciences
Volume1160
ISSN (Print)0077-8923
ISSN (Electronic)1749-6632

Fingerprint

Relaxin
Leiomyoma
Caveolin 1
Phosphorylation
Desmin
Peptide Receptors
Steroid Receptors
Transforming Growth Factors
Transcription
Rats
Tumors
Insulin
Tissue
Peptides
Myometrium
Reverse Transcription
Down-Regulation
Polymerase Chain Reaction
Etiology
Organs

Keywords

  • INSL3
  • Leiomyoma
  • Phospho-SMAD2
  • Relaxin
  • Transforming growth factor

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

Cite this

Li, Z., Burzawa, J. K., Troung, A., Feng, S., Agoulnik, I. U., Tong, X., ... Agoulnik, A. I. (2009). Relaxin signaling in uterine fibroids. In Relaxin and Related Peptides Fifth International Conference (pp. 374-378). (Annals of the New York Academy of Sciences; Vol. 1160). Blackwell Publishing Inc.. https://doi.org/10.1111/j.1749-6632.2008.03803.x

Relaxin signaling in uterine fibroids. / Li, Zhen; Burzawa, Jennifer Kelly; Troung, Anne; Feng, Shu; Agoulnik, Irina U.; Tong, Xiaowen; Anderson, Matthew L.; Kovanci, Ertug; Rajkovic, Aleksandar; Agoulnik, Alexander I.

Relaxin and Related Peptides Fifth International Conference. Blackwell Publishing Inc., 2009. p. 374-378 (Annals of the New York Academy of Sciences; Vol. 1160).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Li, Z, Burzawa, JK, Troung, A, Feng, S, Agoulnik, IU, Tong, X, Anderson, ML, Kovanci, E, Rajkovic, A & Agoulnik, AI 2009, Relaxin signaling in uterine fibroids. in Relaxin and Related Peptides Fifth International Conference. Annals of the New York Academy of Sciences, vol. 1160, Blackwell Publishing Inc., pp. 374-378. https://doi.org/10.1111/j.1749-6632.2008.03803.x
Li Z, Burzawa JK, Troung A, Feng S, Agoulnik IU, Tong X et al. Relaxin signaling in uterine fibroids. In Relaxin and Related Peptides Fifth International Conference. Blackwell Publishing Inc. 2009. p. 374-378. (Annals of the New York Academy of Sciences). https://doi.org/10.1111/j.1749-6632.2008.03803.x
Li, Zhen ; Burzawa, Jennifer Kelly ; Troung, Anne ; Feng, Shu ; Agoulnik, Irina U. ; Tong, Xiaowen ; Anderson, Matthew L. ; Kovanci, Ertug ; Rajkovic, Aleksandar ; Agoulnik, Alexander I. / Relaxin signaling in uterine fibroids. Relaxin and Related Peptides Fifth International Conference. Blackwell Publishing Inc., 2009. pp. 374-378 (Annals of the New York Academy of Sciences).
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