Reliable fluorine-18 [18F-] production at high beam power

Roberto Strangis, Carlos Gonzalez Lepera

Research output: Contribution to conferencePaperpeer-review

Abstract

Demand for 18F for the synthesis of the glucose analog Fluorodeoxyglucose 18F[FDG] and other radiopharma-ceuticals for Positron Emission Tomography (PET) has been increasing very rapidly over the past few years. Small volume (< 5 ml) liquid targets are routinely used for production of 18F and other radiotracers. Among other considerations, power dissipation is a key concept in the design of these targets to be able to accommodate over two kilowatts of beam power. In addition, plumbing, instrumentation and control of target operations have to be properly selected to perform well under harsh temperature, pressure and radiation conditions. An automated liquid transfer system for this type of targets was developed and has been in daily operations for more than three years at our facility. System reliability resulted in improved production, minimum maintenance and reduced radiation exposure to the personnel. A description of this system, its components, materials, instrumentation and software will be presented in this paper. Furthermore, reliability issues of previously existing components due to radiation damage will be discussed.

Original languageEnglish (US)
Pages251-253
Number of pages3
StatePublished - 2007
Event18th International Conference on Cyclotrons and Their Applications 2007, CYCLOTRONS 2007 - Giardini Naxos, Italy
Duration: Oct 1 2007Oct 5 2007

Other

Other18th International Conference on Cyclotrons and Their Applications 2007, CYCLOTRONS 2007
Country/TerritoryItaly
CityGiardini Naxos
Period10/1/0710/5/07

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics

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