Renal function after tandem high-dose chemotherapy and autologous stem cell transplantation in children with Wilms tumor

Soo Hyun Lee, Kyung Hoon Paik, Ki Woong Sung, Meong Hi Son, Keon Hee Yoo, Hong Hoe Koo, Ju Youn Kim, Eun Joo Cho

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Despite increasing evidence that tandem HDCT and autoSCT might improve the survival of patients with high-risk solid tumors, patients with Wilms tumor may be at high risk of acute and chronic renal impairment during and after tandem HDCT/autoSCT because they usually have a single kidney. We investigated the feasibility of tandem HDCT/autoSCT in patients with Wilms tumor, focusing on renal function. Six patients with relapsed/progressed Wilms tumor were assigned to undergo tandem HDCT/autoSCT. One patient developed transient ARF during the first HDCT/autoSCT. All other patients underwent the second HDCT/autoSCT as scheduled. Acute renal dysfunction during the second HDCT/autoSCT was transient and manageable. Indicators of glomerular function such as creatinine clearance, serum creatinine, and albumin excretion were in the normal range at three yr after tandem HDCT/autoSCT. Subclinical tubular dysfunctions, such as increased excretion of β-N-acetylglucosaminidase and β2-microglobulin, were identified at one and three yr after tandem HDCT/autoSCT; however, no patient required treatment for these conditions. These results are helpful to consider tandem HDCT/autoSCT as a treatment option in patients with Wilms tumor. Longer duration of follow-up and close monitoring of tubular function are required if tandem HDCT/autoSCT is indicated in patients with Wilms tumor.

Original languageEnglish (US)
Pages (from-to)855-860
Number of pages6
JournalPediatric Transplantation
Volume15
Issue number8
DOIs
StatePublished - Dec 1 2011

Keywords

  • autologous transplantation
  • glomerular function
  • high-dose chemotherapy
  • tubular function
  • Wilms tumor

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Transplantation

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