Repeat Radiation in the Brain: Managing Patients With Locally Recurrent Glioma

Daniel M. Trifiletti; Timothy D. Malouff; Susan L. McGovern; Shiao Pei Weathers; Tony J.C. Wang; Andrew B. Lassman; Daniel P. Cahill; Helen A. Shih; Paul D. Brown

doi:10.1016/j.semradonc.2020.02.005

Repeat Radiation in the Brain: Managing Patients With Locally Recurrent Glioma

Daniel M. Trifiletti, Timothy D. Malouff, Susan L. McGovern, Shiao Pei Weathers, Tony J.C. Wang, Andrew B. Lassman, Daniel P. Cahill, Helen A. Shih, Paul D. Brown

Research output: Contribution to journal › Review article › peer-review

3 Scopus citations

Abstract

Treatment of recurrent gliomas is especially challenging, as many of these patients have previously been treated with extensive surgery, radiation, or systemic therapy. Due to this, the optimum therapy for patients with recurrent glioma is controversial, with widely variable practice patterns. In this opinion piece, a multidisciplinary panel of experts provides rationale for their treatment approach in a patient with recurrent glioma following subtotal resection with adjuvant chemoradiation for an anaplastic astrocytoma. In summary, the consensus of the panel was to recommend re-resection if possible with hypofractionated radiotherapy schedules, with re-irradiation and systemic therapy as directed by a multidisciplinary team through repeat analysis of the tumor specimen for an updated mutational burden.

Original language	English (US)
Pages (from-to)	218-222
Number of pages	5
Journal	Seminars in radiation oncology
Volume	30
Issue number	3
DOIs	https://doi.org/10.1016/j.semradonc.2020.02.005
State	Published - Jul 2020

ASJC Scopus subject areas

Oncology
Radiology Nuclear Medicine and imaging
Cancer Research

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10.1016/j.semradonc.2020.02.005

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@article{72e57972baa84141a2cc653d45f5cd41,

title = "Repeat Radiation in the Brain: Managing Patients With Locally Recurrent Glioma",

abstract = "Treatment of recurrent gliomas is especially challenging, as many of these patients have previously been treated with extensive surgery, radiation, or systemic therapy. Due to this, the optimum therapy for patients with recurrent glioma is controversial, with widely variable practice patterns. In this opinion piece, a multidisciplinary panel of experts provides rationale for their treatment approach in a patient with recurrent glioma following subtotal resection with adjuvant chemoradiation for an anaplastic astrocytoma. In summary, the consensus of the panel was to recommend re-resection if possible with hypofractionated radiotherapy schedules, with re-irradiation and systemic therapy as directed by a multidisciplinary team through repeat analysis of the tumor specimen for an updated mutational burden.",

author = "Trifiletti, {Daniel M.} and Malouff, {Timothy D.} and McGovern, {Susan L.} and Weathers, {Shiao Pei} and Wang, {Tony J.C.} and Lassman, {Andrew B.} and Cahill, {Daniel P.} and Shih, {Helen A.} and Brown, {Paul D.}",

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year = "2020",

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doi = "10.1016/j.semradonc.2020.02.005",

language = "English (US)",

volume = "30",

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TY - JOUR

T1 - Repeat Radiation in the Brain

T2 - Managing Patients With Locally Recurrent Glioma

AU - Trifiletti, Daniel M.

AU - Malouff, Timothy D.

AU - McGovern, Susan L.

AU - Weathers, Shiao Pei

AU - Wang, Tony J.C.

AU - Lassman, Andrew B.

AU - Cahill, Daniel P.

AU - Shih, Helen A.

AU - Brown, Paul D.

PY - 2020/7

Y1 - 2020/7

N2 - Treatment of recurrent gliomas is especially challenging, as many of these patients have previously been treated with extensive surgery, radiation, or systemic therapy. Due to this, the optimum therapy for patients with recurrent glioma is controversial, with widely variable practice patterns. In this opinion piece, a multidisciplinary panel of experts provides rationale for their treatment approach in a patient with recurrent glioma following subtotal resection with adjuvant chemoradiation for an anaplastic astrocytoma. In summary, the consensus of the panel was to recommend re-resection if possible with hypofractionated radiotherapy schedules, with re-irradiation and systemic therapy as directed by a multidisciplinary team through repeat analysis of the tumor specimen for an updated mutational burden.

AB - Treatment of recurrent gliomas is especially challenging, as many of these patients have previously been treated with extensive surgery, radiation, or systemic therapy. Due to this, the optimum therapy for patients with recurrent glioma is controversial, with widely variable practice patterns. In this opinion piece, a multidisciplinary panel of experts provides rationale for their treatment approach in a patient with recurrent glioma following subtotal resection with adjuvant chemoradiation for an anaplastic astrocytoma. In summary, the consensus of the panel was to recommend re-resection if possible with hypofractionated radiotherapy schedules, with re-irradiation and systemic therapy as directed by a multidisciplinary team through repeat analysis of the tumor specimen for an updated mutational burden.

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JO - Seminars in radiation oncology

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Repeat Radiation in the Brain: Managing Patients With Locally Recurrent Glioma

Abstract

ASJC Scopus subject areas

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