Reply to Comment on 'Linear energy transfer incorporated intensity modulated proton therapy optimization'

Wenhua Cao; Azin Khabazian; Pablo Yepes; Gino Lim; Falk Poenisch; David Grosshans; Radhe Mohan

doi:10.1088/1361-6560/aaff72

Reply to Comment on 'Linear energy transfer incorporated intensity modulated proton therapy optimization'

Wenhua Cao, Azin Khabazian, Pablo Yepes, Gino Lim, Falk Poenisch, David Grosshans, Radhe Mohan

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

In this reply we present additional description of our linear model for LET optimization in response to the comments by Dr Gorissen. We clarify that this model cannot guarantee global optimal solutions to the sum-of-fractions problem. Based on our data, it could be used to optimize LET efficiently while dose constraints are maintained.

Original language	English (US)
Article number	058002
Journal	Physics in medicine and biology
Volume	64
Issue number	5
DOIs	https://doi.org/10.1088/1361-6560/aaff72
State	Published - 2019

Keywords

Intensity modulated proton therapy
linear energy tranfer
optimization

ASJC Scopus subject areas

Radiological and Ultrasound Technology
Radiology Nuclear Medicine and imaging

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10.1088/1361-6560/aaff72

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abstract = "In this reply we present additional description of our linear model for LET optimization in response to the comments by Dr Gorissen. We clarify that this model cannot guarantee global optimal solutions to the sum-of-fractions problem. Based on our data, it could be used to optimize LET efficiently while dose constraints are maintained.",

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AU - Yepes, Pablo

AU - Lim, Gino

AU - Poenisch, Falk

AU - Grosshans, David

AU - Mohan, Radhe

PY - 2019

Y1 - 2019

N2 - In this reply we present additional description of our linear model for LET optimization in response to the comments by Dr Gorissen. We clarify that this model cannot guarantee global optimal solutions to the sum-of-fractions problem. Based on our data, it could be used to optimize LET efficiently while dose constraints are maintained.

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KW - linear energy tranfer

KW - optimization

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Reply to Comment on 'Linear energy transfer incorporated intensity modulated proton therapy optimization'

Abstract

Keywords

ASJC Scopus subject areas

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