Abstract
Pancreatoblastoma is a rare tumor of the pancreas in children, with favorable prognosis if completely resected. If unresectable, neoadjuvant chemotherapy with cisplatin-based regimens are commonly used with good response that allows for resection. For locally aggressive or metastatic disease, neoadjuvant chemotherapy has been reported. Treatment for relapsed or refractory cases is based on anecdotal experiences. We report 2 cases of relapsing pancreatoblastoma with clinical and radiologic response to vinorelbine and cyclophosphamide. Although cure was not achieved, this combination can be offered as an easily tolerated alternative to aggressive chemotherapy for relapsed cases in a palliative setting.
Original language | English (US) |
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Pages (from-to) | e378-e380 |
Journal | Journal of Pediatric Hematology/Oncology |
Volume | 37 |
Issue number | 6 |
DOIs | |
State | Published - Aug 6 2015 |
Keywords
- cyclophosphamide
- pancreatoblastoma
- relapse
- vinorelbine
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Hematology
- Oncology