Response to Preoperative Therapy in Localized Pancreatic Cancer

Giampaolo Perri; Laura R. Prakash; Matthew H.G. Katz

doi:10.3389/fonc.2020.00516

Response to Preoperative Therapy in Localized Pancreatic Cancer

Giampaolo Perri, Laura R. Prakash, Matthew H.G. Katz

Surgical Oncology

Research output: Contribution to journal › Review article › peer-review

15 Scopus citations

Abstract

Evaluation of response to preoperative therapy for patients with pancreatic adenocarcinoma has been historically difficult. Therefore, preoperative regimens have generally been selected on the basis of baseline data such as radiographic stage and serum CA 19-9 level and then typically administered for a pre-specified duration as long as 6 months or more. The decision to proceed with resection following preoperative therapy likewise has rested upon the absence of disease progression rather than evidence for tumor response. This article reviews the basis for the evaluation of therapeutic response after preoperative therapy for pancreatic cancer in the existing scientific literature, and providing updates and new perspectives.

Original language	English (US)
Article number	516
Journal	Frontiers in Oncology
Volume	10
DOIs	https://doi.org/10.3389/fonc.2020.00516
State	Published - Apr 15 2020

Keywords

pancreatic cancer
pathologic response
preoperative therapy
radiographic response
tumor response

ASJC Scopus subject areas

Oncology
Cancer Research

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10.3389/fonc.2020.00516

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title = "Response to Preoperative Therapy in Localized Pancreatic Cancer",

abstract = "Evaluation of response to preoperative therapy for patients with pancreatic adenocarcinoma has been historically difficult. Therefore, preoperative regimens have generally been selected on the basis of baseline data such as radiographic stage and serum CA 19-9 level and then typically administered for a pre-specified duration as long as 6 months or more. The decision to proceed with resection following preoperative therapy likewise has rested upon the absence of disease progression rather than evidence for tumor response. This article reviews the basis for the evaluation of therapeutic response after preoperative therapy for pancreatic cancer in the existing scientific literature, and providing updates and new perspectives.",

keywords = "pancreatic cancer, pathologic response, preoperative therapy, radiographic response, tumor response",

author = "Giampaolo Perri and Prakash, {Laura R.} and Katz, {Matthew H.G.}",

note = "Publisher Copyright: {\textcopyright} Copyright {\textcopyright} 2020 Perri, Prakash and Katz.",

year = "2020",

month = apr,

day = "15",

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language = "English (US)",

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TY - JOUR

T1 - Response to Preoperative Therapy in Localized Pancreatic Cancer

AU - Perri, Giampaolo

AU - Prakash, Laura R.

AU - Katz, Matthew H.G.

PY - 2020/4/15

Y1 - 2020/4/15

N2 - Evaluation of response to preoperative therapy for patients with pancreatic adenocarcinoma has been historically difficult. Therefore, preoperative regimens have generally been selected on the basis of baseline data such as radiographic stage and serum CA 19-9 level and then typically administered for a pre-specified duration as long as 6 months or more. The decision to proceed with resection following preoperative therapy likewise has rested upon the absence of disease progression rather than evidence for tumor response. This article reviews the basis for the evaluation of therapeutic response after preoperative therapy for pancreatic cancer in the existing scientific literature, and providing updates and new perspectives.

AB - Evaluation of response to preoperative therapy for patients with pancreatic adenocarcinoma has been historically difficult. Therefore, preoperative regimens have generally been selected on the basis of baseline data such as radiographic stage and serum CA 19-9 level and then typically administered for a pre-specified duration as long as 6 months or more. The decision to proceed with resection following preoperative therapy likewise has rested upon the absence of disease progression rather than evidence for tumor response. This article reviews the basis for the evaluation of therapeutic response after preoperative therapy for pancreatic cancer in the existing scientific literature, and providing updates and new perspectives.

KW - pancreatic cancer

KW - pathologic response

KW - preoperative therapy

KW - radiographic response

KW - tumor response

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VL - 10

JO - Frontiers in Oncology

JF - Frontiers in Oncology

M1 - 516

ER -

Response to Preoperative Therapy in Localized Pancreatic Cancer

Abstract

Keywords

ASJC Scopus subject areas

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