TY - JOUR
T1 - Resting heart rate is associated with metabolic syndrome and predicted 10-year risk of cardiovascular disease
T2 - a cross-sectional study
AU - Wu, Xueyan
AU - Du, Rui
AU - Hu, Chunyan
AU - Cheng, Di
AU - Ma, Lina
AU - Li, Mian
AU - Xu, Yu
AU - Xu, Min
AU - Chen, Yuhong
AU - Li, Donghui
AU - Bi, Yufang
AU - Wang, Weiqing
AU - Ning, Guang
AU - Lu, Jieli
N1 - Funding Information:
information Ministry of Science and Technology of the People's Republic of China, Grant/Award Number: 2016YFC1305202; Shanghai Sailing Program, Grant/Award Number: 17YF1416800; the National Natural Science Foundation of China, Grant/Award Number: 81670795; Shanghai Committee of Science and Technology of China, Grant/Award Number: 15411966600; Shanghai Jiaotong University, Shuguang Program, Grant/Award Number: 15SG15; Gaofeng Clinical Medicine Grant Support (20152202) from Shanghai Municipal Education Commission. The authors thank the field staff for their contribution to the study and the participants for their cooperation.
Publisher Copyright:
© 2019 Ruijin Hospital, Shanghai Jiaotong University School of Medicine and John Wiley & Sons Australia, Ltd
PY - 2019/11/1
Y1 - 2019/11/1
N2 - Background: This study examined whether resting heart rate (RHR) was associated with metabolic syndrome (MetS) and the 10-year predicted risk of cardiovascular disease in a Chinese population. Methods: The associations of RHR with MetS and 10-year risk of atherosclerotic cardiovascular diseases (ASCVD) was examined in a cross-sectional study conducted in Shanghai, China (n = 9486). Results: Compared with individuals in the lowest RHR quintile (≤71 b.p.m.), those in the highest quintile (≥91 b.p.m.) had a higher prevalence of MetS (21.2% vs 32.6%, respectively; P < 0.001). Logistic regression analyses showed that the multivariate-adjusted odds ratio (OR) and 95% confidence interval (CI) for MetS was 1.13 (1.08-1.18) for each 10-b.p.m. increment of RHR (P < 0.0001). Furthermore, RHR was strongly associated with the prevalence of hypertension, high blood glucose, and dyslipidemia, but not with central obesity. A stronger association of RHR with MetS was observed among individuals aged <65 years, male, with a body mass index <24 kg/m2, without diabetes, hypertension, abnormal lipids, and insulin resistance than among their counterparts (P < 0.05 for all). A significantly higher 10-year risk for ASCVD was observed with each 10-b.p.m. increment in RHR in both men and women (ORs [95% CIs] 1.20 [1.07-1.33] and 1.28 [1.17-1.39], respectively; Ptrend = 0.002 and < 0.0001, respectively). Conclusions: In this study, RHR was associated with a higher prevalence of MetS and elevated 10-year predicted risk of ASCVD in both Chinese men and women. Whether RHR may serve as an indicator for MetS among relatively healthy individuals requires further investigation.
AB - Background: This study examined whether resting heart rate (RHR) was associated with metabolic syndrome (MetS) and the 10-year predicted risk of cardiovascular disease in a Chinese population. Methods: The associations of RHR with MetS and 10-year risk of atherosclerotic cardiovascular diseases (ASCVD) was examined in a cross-sectional study conducted in Shanghai, China (n = 9486). Results: Compared with individuals in the lowest RHR quintile (≤71 b.p.m.), those in the highest quintile (≥91 b.p.m.) had a higher prevalence of MetS (21.2% vs 32.6%, respectively; P < 0.001). Logistic regression analyses showed that the multivariate-adjusted odds ratio (OR) and 95% confidence interval (CI) for MetS was 1.13 (1.08-1.18) for each 10-b.p.m. increment of RHR (P < 0.0001). Furthermore, RHR was strongly associated with the prevalence of hypertension, high blood glucose, and dyslipidemia, but not with central obesity. A stronger association of RHR with MetS was observed among individuals aged <65 years, male, with a body mass index <24 kg/m2, without diabetes, hypertension, abnormal lipids, and insulin resistance than among their counterparts (P < 0.05 for all). A significantly higher 10-year risk for ASCVD was observed with each 10-b.p.m. increment in RHR in both men and women (ORs [95% CIs] 1.20 [1.07-1.33] and 1.28 [1.17-1.39], respectively; Ptrend = 0.002 and < 0.0001, respectively). Conclusions: In this study, RHR was associated with a higher prevalence of MetS and elevated 10-year predicted risk of ASCVD in both Chinese men and women. Whether RHR may serve as an indicator for MetS among relatively healthy individuals requires further investigation.
KW - cardiovascular diseases
KW - heart rate
KW - metabolic syndrome
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U2 - 10.1111/1753-0407.12927
DO - 10.1111/1753-0407.12927
M3 - Article
C2 - 30941862
AN - SCOPUS:85065253754
SN - 1753-0393
VL - 11
SP - 884
EP - 894
JO - Journal of Diabetes
JF - Journal of Diabetes
IS - 11
ER -