Rethinking immune states in brain metastasis

Xiangliang Yuan; Dihua Yu

doi:10.1016/j.ccell.2026.03.019

Rethinking immune states in brain metastasis

Molecular & Cellular Oncology

Research output: Contribution to journal › Comment/debate › peer-review

Abstract

In this issue of Cancer Cell, Jassowicz et al. integrate multimodal profiling of 156 breast cancer brain metastases (BCBMs), challenging the prevailing perception that BCBMs are uniformly immune cold. The study reveals two distinct immune niches of prognostically favorable BCBMs, suggesting potential clinical biomarkers and two routes to antitumor immunity.

Original language	English (US)
Pages (from-to)	1116-1118
Number of pages	3
Journal	Cancer cell
Volume	44
Issue number	6
DOIs	https://doi.org/10.1016/j.ccell.2026.03.019
State	Published - Jun 8 2026

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1016/j.ccell.2026.03.019

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title = "Rethinking immune states in brain metastasis",

abstract = "In this issue of Cancer Cell, Jassowicz et al. integrate multimodal profiling of 156 breast cancer brain metastases (BCBMs), challenging the prevailing perception that BCBMs are uniformly immune cold. The study reveals two distinct immune niches of prognostically favorable BCBMs, suggesting potential clinical biomarkers and two routes to antitumor immunity.",

author = "Xiangliang Yuan and Dihua Yu",

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language = "English (US)",

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AU - Yu, Dihua

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N2 - In this issue of Cancer Cell, Jassowicz et al. integrate multimodal profiling of 156 breast cancer brain metastases (BCBMs), challenging the prevailing perception that BCBMs are uniformly immune cold. The study reveals two distinct immune niches of prognostically favorable BCBMs, suggesting potential clinical biomarkers and two routes to antitumor immunity.

AB - In this issue of Cancer Cell, Jassowicz et al. integrate multimodal profiling of 156 breast cancer brain metastases (BCBMs), challenging the prevailing perception that BCBMs are uniformly immune cold. The study reveals two distinct immune niches of prognostically favorable BCBMs, suggesting potential clinical biomarkers and two routes to antitumor immunity.

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UR - https://www.scopus.com/pages/publications/105037397230#tab=citedBy

U2 - 10.1016/j.ccell.2026.03.019

DO - 10.1016/j.ccell.2026.03.019

M3 - Comment/debate

C2 - 42030929

AN - SCOPUS:105037397230

SN - 1535-6108

VL - 44

SP - 1116

EP - 1118

JO - Cancer cell

JF - Cancer cell

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ER -

Rethinking immune states in brain metastasis

Abstract

ASJC Scopus subject areas

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