Abstract
The effect of aqueous garlic (Allium sativum Linn.) on retinoic acid receptor β (RARβ) mRNA expression was investigated in male Syrian hamsters during 12-dimethyl enz[a]anthracene (DMBA)-induced hamster buccal pouch (HBP) carcinogenesis. RARβ mRNA expression was analysed by slot blotted hybridization with radiolabelled RAR-β probe. In DMBA-induced HBP tumours, decreased expression of RARβ mRNA was observed. Administration of garlic (250 mg/kg body weight) to animals painted with DMBA restored RARβ mRNA expression to normal pattern suggesting that this may be one of the mechanisms by which garlic exerts its chemopreventive effects.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 215-218 |
| Number of pages | 4 |
| Journal | Asia Pacific journal of clinical nutrition |
| Volume | 12 |
| Issue number | 2 |
| State | Published - 2003 |
| Externally published | Yes |
Keywords
- 7,12-dimethylbenz[a]anthracene (DMBA)
- Chemoprevention
- Garlic
- Oral cancer
- Retinoic acid receptor-β
ASJC Scopus subject areas
- Medicine (miscellaneous)
- Nutrition and Dietetics
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