Retraction note: sFRP2 in the aged microenvironment drives melanoma metastasis and therapy resistance (Nature, (2016), 532, 7598, (250-254), 10.1038/nature17392)

Amanpreet Kaur; Marie R. Webster; Katie Marchbank; Reeti Behera; Abibatou Ndoye; Curtis H. Kugel; Vanessa M. Dang; Jessica Appleton; Michael P. O’Connell; Phil Cheng; Alexander A. Valiga; Rachel Morissette; Nazli B. McDonnell; Luigi Ferrucci; Andrew V. Kossenkov; Katrina Meeth; Hsin Yao Tang; Xiangfan Yin; William H. Wood; Elin Lehrmann; Kevin G. Becker; Keith T. Flaherty; Dennie T. Frederick; Jennifer A. Wargo; Zachary A. Cooper; Michael T. Tetzlaff; Courtney Hudgens; Katherine M. Aird; Rugang Zhang; Xiaowei Xu; Qin Liu; Edmund Bartlett; Giorgos Karakousis; Zeynep Eroglu; Roger S. Lo; Matthew Chan; Alexander M. Menzies; Georgina V. Long; Douglas B. Johnson; Jeffrey Sosman; Bastian Schilling; Dirk Schadendorf; David W. Speicher; Marcus Bosenberg; Antoni Ribas; Ashani T. Weeraratna

doi:10.1038/s41586-025-09719-z

Retraction note: sFRP2 in the aged microenvironment drives melanoma metastasis and therapy resistance (Nature, (2016), 532, 7598, (250-254), 10.1038/nature17392)

Amanpreet Kaur
, Marie R. Webster
, Katie Marchbank
, Reeti Behera
, Abibatou Ndoye
, Curtis H. Kugel
, Vanessa M. Dang
, Jessica Appleton
, Michael P. O’Connell
, Phil Cheng
, Alexander A. Valiga
, Rachel Morissette
, Nazli B. McDonnell
, Luigi Ferrucci
, Andrew V. Kossenkov
, Katrina Meeth
, Hsin Yao Tang
, Xiangfan Yin
, William H. Wood
, Elin Lehrmann

Kevin G. Becker, Keith T. Flaherty, Dennie T. Frederick, Jennifer A. Wargo, Zachary A. Cooper, Michael T. Tetzlaff, Courtney Hudgens, Katherine M. Aird, Rugang Zhang, Xiaowei Xu, Qin Liu, Edmund Bartlett, Giorgos Karakousis, Zeynep Eroglu, Roger S. Lo, Matthew Chan, Alexander M. Menzies, Georgina V. Long, Douglas B. Johnson, Jeffrey Sosman, Bastian Schilling, Dirk Schadendorf, David W. Speicher, Marcus Bosenberg, Antoni Ribas, Ashani T. Weeraratna

Research output: Contribution to journal › Comment/debate › peer-review

Abstract

Retraction to: Naturehttps://doi.org/10.1038/nature17392 Published online 4 April 2016 The Editors are retracting this article. After being alerted of several issues with the data presented, an editorial investigation revealed that some results in Extended Data Fig. 9e are no longer statistically significant, which affects the conclusions about therapy resistance as presented in the published study. In addition, several errors in image and source data consistency as well as stated sample numbers were identified in Figs. 1, 3a, 5, Extended Data Figs. 4b, 5c and 9c. Luigi Ferrucci, Hsin-Yao Tang, Rugang Zhang and Roger S. Lo, agree with this retraction. Amanpreet Kaur, Marie R. Webster, Katie Marchbank, Reeti Behera, Abibatou Ndoye, Curtis H. Kugel III, Vanessa M. Dang, Michael P. O’Connell, Phil Cheng, Rachel Morissette, Andrew V. Kossenkov, William H. Wood III, Elin Lehrmann, Kevin G. Becker, Keith T. Flaherty, Jennifer A. Wargo, Katherine M. Aird, Xiaowei Xu, Qin Liu, Giorgos Karakousis, Zeynep Eroglu, Alexander M. Menzies, Georgina V. Long, Douglas B. Johnson, Dirk Schadendorf, Marcus Bosenberg, Antoni Ribas and Ashani T. Weeraratna do not agree with this retraction. Nature was not able to get a response from Jessica Appleton, Alexander A. Valiga, Nazli B. McDonnell, Xiangfan Yin, Dennie T. Frederick, Zachary A. Cooper, Michael T. Tetzlaff, Courtney Hudgens, Edmund Bartlett, Jeffrey Sosman, Bastian Schilling, Katrina Meeth, Matthew Chan and David W. Speicher.

Original language	English (US)
Pages (from-to)	544
Number of pages	1
Journal	Nature
Volume	647
Issue number	8089
DOIs	https://doi.org/10.1038/s41586-025-09719-z
State	Published - Nov 13 2025

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Kaur, A., Webster, M. R., Marchbank, K., Behera, R., Ndoye, A., Kugel, C. H., Dang, V. M., Appleton, J., O’Connell, M. P., Cheng, P., Valiga, A. A., Morissette, R., McDonnell, N. B., Ferrucci, L., Kossenkov, A. V., Meeth, K., Tang, H. Y., Yin, X., Wood, W. H., ... Weeraratna, A. T. (2025). Retraction note: sFRP2 in the aged microenvironment drives melanoma metastasis and therapy resistance (Nature, (2016), 532, 7598, (250-254), 10.1038/nature17392). Nature, 647(8089), 544. https://doi.org/10.1038/s41586-025-09719-z

Kaur, A, Webster, MR, Marchbank, K, Behera, R, Ndoye, A, Kugel, CH, Dang, VM, Appleton, J, O’Connell, MP, Cheng, P, Valiga, AA, Morissette, R, McDonnell, NB, Ferrucci, L, Kossenkov, AV, Meeth, K, Tang, HY, Yin, X, Wood, WH, Lehrmann, E, Becker, KG, Flaherty, KT, Frederick, DT, Wargo, JA, Cooper, ZA, Tetzlaff, MT, Hudgens, C, Aird, KM, Zhang, R, Xu, X, Liu, Q, Bartlett, E, Karakousis, G, Eroglu, Z, Lo, RS, Chan, M, Menzies, AM, Long, GV, Johnson, DB, Sosman, J, Schilling, B, Schadendorf, D, Speicher, DW, Bosenberg, M, Ribas, A & Weeraratna, AT 2025, 'Retraction note: sFRP2 in the aged microenvironment drives melanoma metastasis and therapy resistance (Nature, (2016), 532, 7598, (250-254), 10.1038/nature17392)', Nature, vol. 647, no. 8089, pp. 544. https://doi.org/10.1038/s41586-025-09719-z

@article{498e0103bc004fb7b2aa10bd640bc599,

title = "Retraction note: sFRP2 in the aged microenvironment drives melanoma metastasis and therapy resistance (Nature, (2016), 532, 7598, (250-254), 10.1038/nature17392)",

abstract = "Retraction to: Naturehttps://doi.org/10.1038/nature17392 Published online 4 April 2016 The Editors are retracting this article. After being alerted of several issues with the data presented, an editorial investigation revealed that some results in Extended Data Fig. 9e are no longer statistically significant, which affects the conclusions about therapy resistance as presented in the published study. In addition, several errors in image and source data consistency as well as stated sample numbers were identified in Figs. 1, 3a, 5, Extended Data Figs. 4b, 5c and 9c. Luigi Ferrucci, Hsin-Yao Tang, Rugang Zhang and Roger S. Lo, agree with this retraction. Amanpreet Kaur, Marie R. Webster, Katie Marchbank, Reeti Behera, Abibatou Ndoye, Curtis H. Kugel III, Vanessa M. Dang, Michael P. O{\textquoteright}Connell, Phil Cheng, Rachel Morissette, Andrew V. Kossenkov, William H. Wood III, Elin Lehrmann, Kevin G. Becker, Keith T. Flaherty, Jennifer A. Wargo, Katherine M. Aird, Xiaowei Xu, Qin Liu, Giorgos Karakousis, Zeynep Eroglu, Alexander M. Menzies, Georgina V. Long, Douglas B. Johnson, Dirk Schadendorf, Marcus Bosenberg, Antoni Ribas and Ashani T. Weeraratna do not agree with this retraction. Nature was not able to get a response from Jessica Appleton, Alexander A. Valiga, Nazli B. McDonnell, Xiangfan Yin, Dennie T. Frederick, Zachary A. Cooper, Michael T. Tetzlaff, Courtney Hudgens, Edmund Bartlett, Jeffrey Sosman, Bastian Schilling, Katrina Meeth, Matthew Chan and David W. Speicher.",

author = "Amanpreet Kaur and Webster, \{Marie R.\} and Katie Marchbank and Reeti Behera and Abibatou Ndoye and Kugel, \{Curtis H.\} and Dang, \{Vanessa M.\} and Jessica Appleton and O{\textquoteright}Connell, \{Michael P.\} and Phil Cheng and Valiga, \{Alexander A.\} and Rachel Morissette and McDonnell, \{Nazli B.\} and Luigi Ferrucci and Kossenkov, \{Andrew V.\} and Katrina Meeth and Tang, \{Hsin Yao\} and Xiangfan Yin and Wood, \{William H.\} and Elin Lehrmann and Becker, \{Kevin G.\} and Flaherty, \{Keith T.\} and Frederick, \{Dennie T.\} and Wargo, \{Jennifer A.\} and Cooper, \{Zachary A.\} and Tetzlaff, \{Michael T.\} and Courtney Hudgens and Aird, \{Katherine M.\} and Rugang Zhang and Xiaowei Xu and Qin Liu and Edmund Bartlett and Giorgos Karakousis and Zeynep Eroglu and Lo, \{Roger S.\} and Matthew Chan and Menzies, \{Alexander M.\} and Long, \{Georgina V.\} and Johnson, \{Douglas B.\} and Jeffrey Sosman and Bastian Schilling and Dirk Schadendorf and Speicher, \{David W.\} and Marcus Bosenberg and Antoni Ribas and Weeraratna, \{Ashani T.\}",

note = "Publisher Copyright: {\textcopyright} Springer Nature Limited 2025.",

year = "2025",

month = nov,

day = "13",

doi = "10.1038/s41586-025-09719-z",

language = "English (US)",

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TY - JOUR

T1 - Retraction note

T2 - sFRP2 in the aged microenvironment drives melanoma metastasis and therapy resistance (Nature, (2016), 532, 7598, (250-254), 10.1038/nature17392)

AU - Kaur, Amanpreet

AU - Webster, Marie R.

AU - Marchbank, Katie

AU - Behera, Reeti

AU - Ndoye, Abibatou

AU - Kugel, Curtis H.

AU - Dang, Vanessa M.

AU - Appleton, Jessica

AU - O’Connell, Michael P.

AU - Cheng, Phil

AU - Valiga, Alexander A.

AU - Morissette, Rachel

AU - McDonnell, Nazli B.

AU - Ferrucci, Luigi

AU - Kossenkov, Andrew V.

AU - Meeth, Katrina

AU - Tang, Hsin Yao

AU - Yin, Xiangfan

AU - Wood, William H.

AU - Lehrmann, Elin

AU - Becker, Kevin G.

AU - Flaherty, Keith T.

AU - Frederick, Dennie T.

AU - Wargo, Jennifer A.

AU - Cooper, Zachary A.

AU - Tetzlaff, Michael T.

AU - Hudgens, Courtney

AU - Aird, Katherine M.

AU - Zhang, Rugang

AU - Xu, Xiaowei

AU - Liu, Qin

AU - Bartlett, Edmund

AU - Karakousis, Giorgos

AU - Eroglu, Zeynep

AU - Lo, Roger S.

AU - Chan, Matthew

AU - Menzies, Alexander M.

AU - Long, Georgina V.

AU - Johnson, Douglas B.

AU - Sosman, Jeffrey

AU - Schilling, Bastian

AU - Schadendorf, Dirk

AU - Speicher, David W.

AU - Bosenberg, Marcus

AU - Ribas, Antoni

AU - Weeraratna, Ashani T.

PY - 2025/11/13

Y1 - 2025/11/13

N2 - Retraction to: Naturehttps://doi.org/10.1038/nature17392 Published online 4 April 2016 The Editors are retracting this article. After being alerted of several issues with the data presented, an editorial investigation revealed that some results in Extended Data Fig. 9e are no longer statistically significant, which affects the conclusions about therapy resistance as presented in the published study. In addition, several errors in image and source data consistency as well as stated sample numbers were identified in Figs. 1, 3a, 5, Extended Data Figs. 4b, 5c and 9c. Luigi Ferrucci, Hsin-Yao Tang, Rugang Zhang and Roger S. Lo, agree with this retraction. Amanpreet Kaur, Marie R. Webster, Katie Marchbank, Reeti Behera, Abibatou Ndoye, Curtis H. Kugel III, Vanessa M. Dang, Michael P. O’Connell, Phil Cheng, Rachel Morissette, Andrew V. Kossenkov, William H. Wood III, Elin Lehrmann, Kevin G. Becker, Keith T. Flaherty, Jennifer A. Wargo, Katherine M. Aird, Xiaowei Xu, Qin Liu, Giorgos Karakousis, Zeynep Eroglu, Alexander M. Menzies, Georgina V. Long, Douglas B. Johnson, Dirk Schadendorf, Marcus Bosenberg, Antoni Ribas and Ashani T. Weeraratna do not agree with this retraction. Nature was not able to get a response from Jessica Appleton, Alexander A. Valiga, Nazli B. McDonnell, Xiangfan Yin, Dennie T. Frederick, Zachary A. Cooper, Michael T. Tetzlaff, Courtney Hudgens, Edmund Bartlett, Jeffrey Sosman, Bastian Schilling, Katrina Meeth, Matthew Chan and David W. Speicher.

AB - Retraction to: Naturehttps://doi.org/10.1038/nature17392 Published online 4 April 2016 The Editors are retracting this article. After being alerted of several issues with the data presented, an editorial investigation revealed that some results in Extended Data Fig. 9e are no longer statistically significant, which affects the conclusions about therapy resistance as presented in the published study. In addition, several errors in image and source data consistency as well as stated sample numbers were identified in Figs. 1, 3a, 5, Extended Data Figs. 4b, 5c and 9c. Luigi Ferrucci, Hsin-Yao Tang, Rugang Zhang and Roger S. Lo, agree with this retraction. Amanpreet Kaur, Marie R. Webster, Katie Marchbank, Reeti Behera, Abibatou Ndoye, Curtis H. Kugel III, Vanessa M. Dang, Michael P. O’Connell, Phil Cheng, Rachel Morissette, Andrew V. Kossenkov, William H. Wood III, Elin Lehrmann, Kevin G. Becker, Keith T. Flaherty, Jennifer A. Wargo, Katherine M. Aird, Xiaowei Xu, Qin Liu, Giorgos Karakousis, Zeynep Eroglu, Alexander M. Menzies, Georgina V. Long, Douglas B. Johnson, Dirk Schadendorf, Marcus Bosenberg, Antoni Ribas and Ashani T. Weeraratna do not agree with this retraction. Nature was not able to get a response from Jessica Appleton, Alexander A. Valiga, Nazli B. McDonnell, Xiangfan Yin, Dennie T. Frederick, Zachary A. Cooper, Michael T. Tetzlaff, Courtney Hudgens, Edmund Bartlett, Jeffrey Sosman, Bastian Schilling, Katrina Meeth, Matthew Chan and David W. Speicher.

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U2 - 10.1038/s41586-025-09719-z

DO - 10.1038/s41586-025-09719-z

M3 - Comment/debate

C2 - 41162716

AN - SCOPUS:105021322446

SN - 0028-0836

VL - 647

SP - 544

JO - Nature

JF - Nature

IS - 8089

ER -

Retraction note: sFRP2 in the aged microenvironment drives melanoma metastasis and therapy resistance (Nature, (2016), 532, 7598, (250-254), 10.1038/nature17392)

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