Review article: Clinical applications of mesenchymal stem cells in soft tissue augmentation

Summer E. Hanson, Karol A. Gutowski, Peiman Hematti

Research output: Contribution to journalReview articlepeer-review

43 Scopus citations

Abstract

Based on a variety of preclinical studies showing that mesenchymal stem cells (MSC) play a significant role in tissue repair and homeostasis, MSC have rapidly moved into a phase of clinical trials investigating their efficacy as a cell-based therapeutic modality for a diverse group of applications. An emerging body of evidence shows that in addition to being a progenitor cell population with self-renewing and multipotent differentiation capabilities, MSC have unique immunomodulatory properties, making them even more attractive for regenerative medicine. Emerging discoveries in stem cell biology have revealed a multitude of mechanisms through which MSC could potentially augment the current techniques in aesthetic surgery. In this article, the authors review the clinical advances in cell-based therapies relevant to aesthetic surgery, including tissue augmentation, rejuvenation, and regeneration.

Original languageEnglish (US)
Pages (from-to)838-842
Number of pages5
JournalAesthetic surgery journal
Volume30
Issue number6
DOIs
StatePublished - Dec 2010

Keywords

  • cosmetic augmentation
  • fat grafting
  • immune modulation
  • mesenchymal stem cells

ASJC Scopus subject areas

  • Surgery

Fingerprint

Dive into the research topics of 'Review article: Clinical applications of mesenchymal stem cells in soft tissue augmentation'. Together they form a unique fingerprint.

Cite this