Review of the adipose derived stem cell secretome

Sahil K. Kapur, Adam J. Katz

Research output: Contribution to journalReview articlepeer-review

253 Scopus citations

Abstract

Recent advances in protein detection and analysis have lead to multiple in depth studies that analyze the adipose-derived stem cell (ASC) secretome. These studies differ significantly in their methods of secretome preparation and analysis. Most of them use a pro-differentiation or pro-inflammatory stimulus to observe differential expression of secreted proteins. In spite of the variance in methodologies used, 68 proteins are reported to be commonly expressed in a majority of the studies and may serve as potential candidates for conserved secretome proteins. Multiple recent clinical and basic science studies demonstrate the beneficial role played by secreted proteins in augmenting ASC effects in scenarios involving angiogenesis, wound healing, tissue regeneration and immunomodulation. Furthermore, 3-D formulations of ASCs that preserve the niche environment of cells and their secreted proteins have also shown enhanced clinical effects. In light of the lack of uniformity in prior secretome-analysis studies, and the growing clinical importance of the ASC secretome, more in depth studies that use uniform and standardized means of protein detection and analysis are necessary.

Original languageEnglish (US)
Pages (from-to)2222-2228
Number of pages7
JournalBiochimie
Volume95
Issue number12
DOIs
StatePublished - Dec 2013
Externally publishedYes

Keywords

  • Adipogenesis
  • Adipose tissue
  • Adipose-derived stem cell (ASC)
  • Niche
  • Secretome
  • Stromal-vascular fraction

ASJC Scopus subject areas

  • Biochemistry

Fingerprint

Dive into the research topics of 'Review of the adipose derived stem cell secretome'. Together they form a unique fingerprint.

Cite this