Risk calculators for hepatocellular carcinoma in patients affected with chronic hepatitis B in Asia

Hwai I. Yang, Mei Hsuan Lee, Jessica Liu, Chien Jen Chen

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Risk calculators are widely used in many clinical fields, and integrate several important risk factors through the conversion of a risk function into a single measure of risk. Several studies have been carried out to create risk calculators for the prediction of hepatocellular carcinoma (HCC) in patients with chronic hepatitis B (CHB). Most of them were hospital-based, with limited sample sizes and insufficient external validation. These study groups collaborated to establish the REACH-B risk score, which incorporated five clinical variables to predict HCC risk. This risk score was then validated in international clinical cohorts. Evidence suggests that quantitative serum HBsAg level provides additional predictability of HCC, especially in patients with low levels of hepatitis B virus DNA. This novel marker was incorporated into a risk calculator and was internally validated. This tool will hopefully be externally validated in the near future. Risk calculators can be used to support clinical practice, and to establish preventive measures; several "off-label" extension usages have also been implemented. Albeit beneficial, several precautions and discussions should be noted in using the risk calculators. The future development of risk calculators for CHB patients can be extended by applying them to additional CHB-related outcomes, and by incorporating emerging risk parameters.

Original languageEnglish (US)
Pages (from-to)6244-6251
Number of pages8
JournalWorld journal of gastroenterology
Volume20
Issue number20
DOIs
StatePublished - May 28 2014

Fingerprint

Chronic Hepatitis B
Hepatocellular Carcinoma
Hepatitis B Surface Antigens
Hepatitis B virus
Sample Size

Keywords

  • Chronic hepatitis B
  • Hepatitis B virus
  • Hepatocellular carcinoma
  • Risk calculator

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Risk calculators for hepatocellular carcinoma in patients affected with chronic hepatitis B in Asia. / Yang, Hwai I.; Lee, Mei Hsuan; Liu, Jessica; Chen, Chien Jen.

In: World journal of gastroenterology, Vol. 20, No. 20, 28.05.2014, p. 6244-6251.

Research output: Contribution to journalArticle

Yang, Hwai I. ; Lee, Mei Hsuan ; Liu, Jessica ; Chen, Chien Jen. / Risk calculators for hepatocellular carcinoma in patients affected with chronic hepatitis B in Asia. In: World journal of gastroenterology. 2014 ; Vol. 20, No. 20. pp. 6244-6251.
@article{ee4d3549d4f44ab0a2e3752aaa72d3c1,
title = "Risk calculators for hepatocellular carcinoma in patients affected with chronic hepatitis B in Asia",
abstract = "Risk calculators are widely used in many clinical fields, and integrate several important risk factors through the conversion of a risk function into a single measure of risk. Several studies have been carried out to create risk calculators for the prediction of hepatocellular carcinoma (HCC) in patients with chronic hepatitis B (CHB). Most of them were hospital-based, with limited sample sizes and insufficient external validation. These study groups collaborated to establish the REACH-B risk score, which incorporated five clinical variables to predict HCC risk. This risk score was then validated in international clinical cohorts. Evidence suggests that quantitative serum HBsAg level provides additional predictability of HCC, especially in patients with low levels of hepatitis B virus DNA. This novel marker was incorporated into a risk calculator and was internally validated. This tool will hopefully be externally validated in the near future. Risk calculators can be used to support clinical practice, and to establish preventive measures; several {"}off-label{"} extension usages have also been implemented. Albeit beneficial, several precautions and discussions should be noted in using the risk calculators. The future development of risk calculators for CHB patients can be extended by applying them to additional CHB-related outcomes, and by incorporating emerging risk parameters.",
keywords = "Chronic hepatitis B, Hepatitis B virus, Hepatocellular carcinoma, Risk calculator",
author = "Yang, {Hwai I.} and Lee, {Mei Hsuan} and Jessica Liu and Chen, {Chien Jen}",
year = "2014",
month = "5",
day = "28",
doi = "10.3748/wjg.v20.i20.6244",
language = "English (US)",
volume = "20",
pages = "6244--6251",
journal = "World Journal of Gastroenterology",
issn = "1007-9327",
publisher = "WJG Press",
number = "20",

}

TY - JOUR

T1 - Risk calculators for hepatocellular carcinoma in patients affected with chronic hepatitis B in Asia

AU - Yang, Hwai I.

AU - Lee, Mei Hsuan

AU - Liu, Jessica

AU - Chen, Chien Jen

PY - 2014/5/28

Y1 - 2014/5/28

N2 - Risk calculators are widely used in many clinical fields, and integrate several important risk factors through the conversion of a risk function into a single measure of risk. Several studies have been carried out to create risk calculators for the prediction of hepatocellular carcinoma (HCC) in patients with chronic hepatitis B (CHB). Most of them were hospital-based, with limited sample sizes and insufficient external validation. These study groups collaborated to establish the REACH-B risk score, which incorporated five clinical variables to predict HCC risk. This risk score was then validated in international clinical cohorts. Evidence suggests that quantitative serum HBsAg level provides additional predictability of HCC, especially in patients with low levels of hepatitis B virus DNA. This novel marker was incorporated into a risk calculator and was internally validated. This tool will hopefully be externally validated in the near future. Risk calculators can be used to support clinical practice, and to establish preventive measures; several "off-label" extension usages have also been implemented. Albeit beneficial, several precautions and discussions should be noted in using the risk calculators. The future development of risk calculators for CHB patients can be extended by applying them to additional CHB-related outcomes, and by incorporating emerging risk parameters.

AB - Risk calculators are widely used in many clinical fields, and integrate several important risk factors through the conversion of a risk function into a single measure of risk. Several studies have been carried out to create risk calculators for the prediction of hepatocellular carcinoma (HCC) in patients with chronic hepatitis B (CHB). Most of them were hospital-based, with limited sample sizes and insufficient external validation. These study groups collaborated to establish the REACH-B risk score, which incorporated five clinical variables to predict HCC risk. This risk score was then validated in international clinical cohorts. Evidence suggests that quantitative serum HBsAg level provides additional predictability of HCC, especially in patients with low levels of hepatitis B virus DNA. This novel marker was incorporated into a risk calculator and was internally validated. This tool will hopefully be externally validated in the near future. Risk calculators can be used to support clinical practice, and to establish preventive measures; several "off-label" extension usages have also been implemented. Albeit beneficial, several precautions and discussions should be noted in using the risk calculators. The future development of risk calculators for CHB patients can be extended by applying them to additional CHB-related outcomes, and by incorporating emerging risk parameters.

KW - Chronic hepatitis B

KW - Hepatitis B virus

KW - Hepatocellular carcinoma

KW - Risk calculator

UR - http://www.scopus.com/inward/record.url?scp=84901486198&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84901486198&partnerID=8YFLogxK

U2 - 10.3748/wjg.v20.i20.6244

DO - 10.3748/wjg.v20.i20.6244

M3 - Article

C2 - 24876745

AN - SCOPUS:84901486198

VL - 20

SP - 6244

EP - 6251

JO - World Journal of Gastroenterology

JF - World Journal of Gastroenterology

SN - 1007-9327

IS - 20

ER -