Risk factors of extubation failure in extremely low birth weight infants: A five year retrospective analysis

Chao Yi Lee, Bai Horng Su, Tsung Wen Lin, Hung Chih Lin, Tsai-Chung Li, Nai Phon Wang

Research output: Contribution to journalArticle

Abstract

Extubation failure is one of the most serious complications in extremely low birth weight infants (ELBWI) on mechanical ventilation tberapy. We performed a 5-year retrospective analysis to realize the status of extubation failure in ELBWI. Extubation failure was defined as requirements of re-intubation within 72 hours after extubation. The extubation failure rate was 21% (29/138). The mean birth body weight was 808.3±140.4 gm. The mean gestational age was 25.8±1.2 wks. The incidence of chronic lung disease (CLD) in infants with extubation failure was 100% (29/29). Apnea of prematurity 49% (14/29) and post-extubation atelectasis 39% (11/29) were the most common reasons for reintubation. The major microbiology findings which correlated with nosocomial pneumonia in infants with extubation failure were Acinetobacter baumanni (21%), Klebsiella pneumonia (21%), Pseudomonas aeroginosa (14%), and Methicillin resistent staphylococcus aureus (14%). In conclusion, post-extubation atelectasis and apnea were the most common reasons for reintubation. ELBWI with extubation failure had higher incidences of post-extubation atelectasis, CLD, and nosocomial pneumonia. Further prospective studies are needed in order to clarify the appropriate extubation program for ELBWI and to prevent post-extubation atelectasis and nosocomial pneumonia.

Original languageEnglish (US)
Pages (from-to)319-325
Number of pages7
JournalActa Paediatrica Taiwanica
Volume43
Issue number6
StatePublished - Nov 1 2002

Fingerprint

Extremely Low Birth Weight Infant
Pulmonary Atelectasis
Pneumonia
Apnea
Lung Diseases
Chronic Disease Hospitals
Acinetobacter
Methicillin
Incidence
Klebsiella pneumoniae
Pseudomonas
Microbiology
Artificial Respiration
Intubation
Birth Weight
Gestational Age
Staphylococcus aureus
Chronic Disease
Body Weight
Prospective Studies

Keywords

  • Extremely low birth weight infant
  • Extubation failure

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Risk factors of extubation failure in extremely low birth weight infants : A five year retrospective analysis. / Lee, Chao Yi; Su, Bai Horng; Lin, Tsung Wen; Lin, Hung Chih; Li, Tsai-Chung; Wang, Nai Phon.

In: Acta Paediatrica Taiwanica, Vol. 43, No. 6, 01.11.2002, p. 319-325.

Research output: Contribution to journalArticle

Lee, Chao Yi ; Su, Bai Horng ; Lin, Tsung Wen ; Lin, Hung Chih ; Li, Tsai-Chung ; Wang, Nai Phon. / Risk factors of extubation failure in extremely low birth weight infants : A five year retrospective analysis. In: Acta Paediatrica Taiwanica. 2002 ; Vol. 43, No. 6. pp. 319-325.
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