Risk of cerebral metastases for postoperative locally advanced non-small-cell lung cancer

Si yu Wang, Xiong Ye, Wei Ou, Yong bin Lin, Bin bin Zhang, Hua Yang

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Background: Cerebral metastases are the main determining factor in the failure of locally advanced non-small-cell lung cancer (NSCLC) management. Our study assessed the risk factors of brain metastases in patients with postoperative, locally advanced NSCLC. Implications for PCI treatment are discussed. Methods: Two hundred twenty-three patients treated with surgical resection for stage III-N2 NSCLC were retrospective analyzed to elucidate risk factors for development of brain metastases, and to establish a mathematical model. Results: Median survival time for this patient population was 29.5 months. Frequency of brain metastases in the entire patient population was 38.1% (85/223). Frequency of brain metastases in patients with single mediastinal lymph-node region with metastases at 1, 2, and 3 years was 5.6%, 14.0%, and 19.0%, respectively. The frequency of brain metastases in patients with multiple mediastinal lymph-node regions with metastases was 31.8%, 60.3%, 68.0%, respectively (P < 0.001). The frequency of brain metastases among patients with mediastinal metastasis number less than 4, 4-6, and more than 6 was significantly different (P < 0.001). There were also significant differences in brain metastases frequency between patients with complete versus incomplete resection (P = 0.001), and patients with non-squmous versus squamous (P = 0.029), and patients administered adjuvant chemotherapy versus none (P = 0.032). Conclusion: A mathematical model to predict brain metastases risk was developed. It can aid in selection of patients with locally advanced NSCLC for PCI in clinical trails.

Original languageEnglish (US)
Pages (from-to)238-243
Number of pages6
JournalLung Cancer
Volume64
Issue number2
DOIs
StatePublished - May 1 2009

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Non-Small Cell Lung Carcinoma
Neoplasm Metastasis
Brain
Theoretical Models
Lymph Nodes
Adjuvant Chemotherapy
Patient Selection
Population
Survival

Keywords

  • Brain metastases
  • Non-small-cell lung cancer
  • Prophylactic cranial irradiation

ASJC Scopus subject areas

  • Oncology
  • Pulmonary and Respiratory Medicine
  • Cancer Research

Cite this

Risk of cerebral metastases for postoperative locally advanced non-small-cell lung cancer. / Wang, Si yu; Ye, Xiong; Ou, Wei; Lin, Yong bin; Zhang, Bin bin; Yang, Hua.

In: Lung Cancer, Vol. 64, No. 2, 01.05.2009, p. 238-243.

Research output: Contribution to journalArticle

Wang, Si yu ; Ye, Xiong ; Ou, Wei ; Lin, Yong bin ; Zhang, Bin bin ; Yang, Hua. / Risk of cerebral metastases for postoperative locally advanced non-small-cell lung cancer. In: Lung Cancer. 2009 ; Vol. 64, No. 2. pp. 238-243.
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