TY - JOUR
T1 - Risks and Benefits of Gadolinium-Based Contrast-Enhanced MRI
AU - Costelloe, Colleen M.
AU - Amini, Behrang
AU - Madewell, John E.
N1 - Publisher Copyright:
© 2019
PY - 2020/4
Y1 - 2020/4
N2 - The responsible use of gadolinium-based contrast agents (GBCAs) requires a balance between safety and clinical utility. While nephrogenic systemic fibrosis (NSF) has been associated with most linear GBCAs few, if any, new cases have been verified since the successful implementation of screening programs to detect renal impairment and prevent susceptible patients from receiving these higher-risk agents. The likelihood of developing nephrogenic systemic fibrosis has been shown to be negligible with macrocyclic agents, prompting the American College of Radiology and other regulatory agencies to suggest that no screening is necessary when they are used. There is no solid evidence of negative clinical effect from the retention of macrocyclic agents in the brain while there is evidence that they wash out of the brain over time. GBCAs have many important clinical uses that can help prevent morbidity or death. This article reviews the risks and benefits of GBCA administration.
AB - The responsible use of gadolinium-based contrast agents (GBCAs) requires a balance between safety and clinical utility. While nephrogenic systemic fibrosis (NSF) has been associated with most linear GBCAs few, if any, new cases have been verified since the successful implementation of screening programs to detect renal impairment and prevent susceptible patients from receiving these higher-risk agents. The likelihood of developing nephrogenic systemic fibrosis has been shown to be negligible with macrocyclic agents, prompting the American College of Radiology and other regulatory agencies to suggest that no screening is necessary when they are used. There is no solid evidence of negative clinical effect from the retention of macrocyclic agents in the brain while there is evidence that they wash out of the brain over time. GBCAs have many important clinical uses that can help prevent morbidity or death. This article reviews the risks and benefits of GBCA administration.
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U2 - 10.1053/j.sult.2019.12.005
DO - 10.1053/j.sult.2019.12.005
M3 - Article
C2 - 32446430
AN - SCOPUS:85077520346
SN - 0887-2171
VL - 41
SP - 170
EP - 182
JO - Seminars in Ultrasound, CT and MRI
JF - Seminars in Ultrasound, CT and MRI
IS - 2
ER -