RNA processing: A new player of genomic instability in multiple myeloma

Matteo Marchesini, Elena Fiorini, Simona Colla

Research output: Contribution to journalEditorialpeer-review

2 Scopus citations

Abstract

Genomic instability, a hallmark of almost all cancers, originates from the combined effects of a deregulated DNA damage response, DNA repair defects, and a failure of cell-cycle checkpoints before the damaged DNA is propagated to daughter cells [1]. Alterations in this network of genomic integrity-preserving pathways lead to the accumulation of mutations, aneuploidy, and chromosomal alterations, the main causes of cancer. Multiple myeloma (MM) is a clonal malignancy of terminally differentiated plasma cells that reside and expand in the bone marrow. MM cells are characterized by a high aneuploidy incidence and recurrent structural chromosomal alterations, features that reflect these cells' underlying genomic instability [2].

Original languageEnglish (US)
Pages (from-to)73-74
Number of pages2
JournalOncoscience
Volume4
Issue number7-8
DOIs
StatePublished - 2017

Keywords

  • DNA damage
  • Genomic instability
  • Multiple myeloma
  • RNA-binding proteins

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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