Roadmap for metal nanoparticles in radiation therapy: Current status, translational challenges, and future directions

Jan Schuemann; Alexander F. Bagley; Ross Berbeco; Kyle Bromma; Karl T. Butterworth; Hilary L. Byrne; B. Devika Chithrani; Sang Hyun Cho; Jason R. Cook; Vincent Favaudon; Yaser H. Gholami; Elisabetta Gargioni; James F. Hainfeld; Félicien Hespeels; Anne Catherine Heuskin; Udoka M. Ibeh; Zdenka Kuncic; Sijumon Kunjachan; Sandrine Lacombe; Stéphane Lucas; François Lux; Stephen McMahon; Dmitry Nevozhay; Wilfred Ngwa; J. Donald Payne; Sébastien Penninckx; Erika Porcel; Kevin M. Prise; Hans Rabus; Sharif M. Ridwan; Benedikt Rudek; Léon Sanche; Bijay Singh; Henry M. Smilowitz; Konstantin V. Sokolov; Srinivas Sridhar; Yaroslav Stanishevskiy; Wonmo Sung; Olivier Tillement; Needa Virani; Wassana Yantasee; Sunil Krishnan

doi:10.1088/1361-6560/ab9159

Roadmap for metal nanoparticles in radiation therapy: Current status, translational challenges, and future directions

Jan Schuemann, Alexander F. Bagley, Ross Berbeco, Kyle Bromma, Karl T. Butterworth, Hilary L. Byrne, B. Devika Chithrani, Sang Hyun Cho, Jason R. Cook, Vincent Favaudon, Yaser H. Gholami, Elisabetta Gargioni, James F. Hainfeld, Félicien Hespeels, Anne Catherine Heuskin, Udoka M. Ibeh, Zdenka Kuncic, Sijumon Kunjachan, Sandrine Lacombe, Stéphane LucasFrançois Lux, Stephen McMahon, Dmitry Nevozhay, Wilfred Ngwa, J. Donald Payne, Sébastien Penninckx, Erika Porcel, Kevin M. Prise, Hans Rabus, Sharif M. Ridwan, Benedikt Rudek, Léon Sanche, Bijay Singh, Henry M. Smilowitz, Konstantin V. Sokolov, Srinivas Sridhar, Yaroslav Stanishevskiy, Wonmo Sung, Olivier Tillement, Needa Virani, Wassana Yantasee, Sunil Krishnan

Research output: Contribution to journal › Article › peer-review

96 Scopus citations

Abstract

This roadmap outlines the potential roles of metallic nanoparticles (MNPs) in the field of radiation therapy. MNPs made up of a wide range of materials (from Titanium, Z = 22, to Bismuth, Z = 83) and a similarly wide spectrum of potential clinical applications, including diagnostic, therapeutic (radiation dose enhancers, hyperthermia inducers, drug delivery vehicles, vaccine adjuvants, photosensitizers, enhancers of immunotherapy) and theranostic (combining both diagnostic and therapeutic), are being fabricated and evaluated. This roadmap covers contributions from experts in these topics summarizing their view of the current status and challenges, as well as expected advancements in technology to address these challenges.

Original language	English (US)
Article number	21RM02
Journal	Physics in medicine and biology
Volume	65
Issue number	21
DOIs	https://doi.org/10.1088/1361-6560/ab9159
State	Published - Nov 7 2020
Externally published	Yes

Keywords

immunotherapy
metal nanoparticles
modeling
nanoparticle imaging
radiotherapy
theranostics
therapeutic applications of nanoparticles

ASJC Scopus subject areas

Radiological and Ultrasound Technology
Radiology Nuclear Medicine and imaging

Access to Document

10.1088/1361-6560/ab9159

Cite this

Schuemann, J., Bagley, A. F., Berbeco, R., Bromma, K., Butterworth, K. T., Byrne, H. L., Chithrani, B. D., Cho, S. H., Cook, J. R., Favaudon, V., Gholami, Y. H., Gargioni, E., Hainfeld, J. F., Hespeels, F., Heuskin, A. C., Ibeh, U. M., Kuncic, Z., Kunjachan, S., Lacombe, S., ... Krishnan, S. (2020). Roadmap for metal nanoparticles in radiation therapy: Current status, translational challenges, and future directions. Physics in medicine and biology, 65(21), Article 21RM02. https://doi.org/10.1088/1361-6560/ab9159

Schuemann, J, Bagley, AF, Berbeco, R, Bromma, K, Butterworth, KT, Byrne, HL, Chithrani, BD, Cho, SH, Cook, JR, Favaudon, V, Gholami, YH, Gargioni, E, Hainfeld, JF, Hespeels, F, Heuskin, AC, Ibeh, UM, Kuncic, Z, Kunjachan, S, Lacombe, S, Lucas, S, Lux, F, McMahon, S, Nevozhay, D, Ngwa, W, Payne, JD, Penninckx, S, Porcel, E, Prise, KM, Rabus, H, Ridwan, SM, Rudek, B, Sanche, L, Singh, B, Smilowitz, HM, Sokolov, KV, Sridhar, S, Stanishevskiy, Y, Sung, W, Tillement, O, Virani, N, Yantasee, W & Krishnan, S 2020, 'Roadmap for metal nanoparticles in radiation therapy: Current status, translational challenges, and future directions', Physics in medicine and biology, vol. 65, no. 21, 21RM02. https://doi.org/10.1088/1361-6560/ab9159

@article{254fa23797e54973a54b6b89dd028595,

title = "Roadmap for metal nanoparticles in radiation therapy: Current status, translational challenges, and future directions",

abstract = "This roadmap outlines the potential roles of metallic nanoparticles (MNPs) in the field of radiation therapy. MNPs made up of a wide range of materials (from Titanium, Z = 22, to Bismuth, Z = 83) and a similarly wide spectrum of potential clinical applications, including diagnostic, therapeutic (radiation dose enhancers, hyperthermia inducers, drug delivery vehicles, vaccine adjuvants, photosensitizers, enhancers of immunotherapy) and theranostic (combining both diagnostic and therapeutic), are being fabricated and evaluated. This roadmap covers contributions from experts in these topics summarizing their view of the current status and challenges, as well as expected advancements in technology to address these challenges.",

keywords = "immunotherapy, metal nanoparticles, modeling, nanoparticle imaging, radiotherapy, theranostics, therapeutic applications of nanoparticles",

author = "Jan Schuemann and Bagley, {Alexander F.} and Ross Berbeco and Kyle Bromma and Butterworth, {Karl T.} and Byrne, {Hilary L.} and Chithrani, {B. Devika} and Cho, {Sang Hyun} and Cook, {Jason R.} and Vincent Favaudon and Gholami, {Yaser H.} and Elisabetta Gargioni and Hainfeld, {James F.} and F{\'e}licien Hespeels and Heuskin, {Anne Catherine} and Ibeh, {Udoka M.} and Zdenka Kuncic and Sijumon Kunjachan and Sandrine Lacombe and St{\'e}phane Lucas and Fran{\c c}ois Lux and Stephen McMahon and Dmitry Nevozhay and Wilfred Ngwa and Payne, {J. Donald} and S{\'e}bastien Penninckx and Erika Porcel and Prise, {Kevin M.} and Hans Rabus and Ridwan, {Sharif M.} and Benedikt Rudek and L{\'e}on Sanche and Bijay Singh and Smilowitz, {Henry M.} and Sokolov, {Konstantin V.} and Srinivas Sridhar and Yaroslav Stanishevskiy and Wonmo Sung and Olivier Tillement and Needa Virani and Wassana Yantasee and Sunil Krishnan",

note = "Publisher Copyright: {\textcopyright} 2020 Institute of Physics and Engineering in Medicine.",

year = "2020",

month = nov,

day = "7",

doi = "10.1088/1361-6560/ab9159",

language = "English (US)",

volume = "65",

journal = "Physics in medicine and biology",

issn = "0031-9155",

publisher = "IOP Publishing Ltd.",

number = "21",

}

TY - JOUR

T1 - Roadmap for metal nanoparticles in radiation therapy

T2 - Current status, translational challenges, and future directions

AU - Schuemann, Jan

AU - Bagley, Alexander F.

AU - Berbeco, Ross

AU - Bromma, Kyle

AU - Butterworth, Karl T.

AU - Byrne, Hilary L.

AU - Chithrani, B. Devika

AU - Cho, Sang Hyun

AU - Cook, Jason R.

AU - Favaudon, Vincent

AU - Gholami, Yaser H.

AU - Gargioni, Elisabetta

AU - Hainfeld, James F.

AU - Hespeels, Félicien

AU - Heuskin, Anne Catherine

AU - Ibeh, Udoka M.

AU - Kuncic, Zdenka

AU - Kunjachan, Sijumon

AU - Lacombe, Sandrine

AU - Lucas, Stéphane

AU - Lux, François

AU - McMahon, Stephen

AU - Nevozhay, Dmitry

AU - Ngwa, Wilfred

AU - Payne, J. Donald

AU - Penninckx, Sébastien

AU - Porcel, Erika

AU - Prise, Kevin M.

AU - Rabus, Hans

AU - Ridwan, Sharif M.

AU - Rudek, Benedikt

AU - Sanche, Léon

AU - Singh, Bijay

AU - Smilowitz, Henry M.

AU - Sokolov, Konstantin V.

AU - Sridhar, Srinivas

AU - Stanishevskiy, Yaroslav

AU - Sung, Wonmo

AU - Tillement, Olivier

AU - Virani, Needa

AU - Yantasee, Wassana

AU - Krishnan, Sunil

PY - 2020/11/7

Y1 - 2020/11/7

N2 - This roadmap outlines the potential roles of metallic nanoparticles (MNPs) in the field of radiation therapy. MNPs made up of a wide range of materials (from Titanium, Z = 22, to Bismuth, Z = 83) and a similarly wide spectrum of potential clinical applications, including diagnostic, therapeutic (radiation dose enhancers, hyperthermia inducers, drug delivery vehicles, vaccine adjuvants, photosensitizers, enhancers of immunotherapy) and theranostic (combining both diagnostic and therapeutic), are being fabricated and evaluated. This roadmap covers contributions from experts in these topics summarizing their view of the current status and challenges, as well as expected advancements in technology to address these challenges.

AB - This roadmap outlines the potential roles of metallic nanoparticles (MNPs) in the field of radiation therapy. MNPs made up of a wide range of materials (from Titanium, Z = 22, to Bismuth, Z = 83) and a similarly wide spectrum of potential clinical applications, including diagnostic, therapeutic (radiation dose enhancers, hyperthermia inducers, drug delivery vehicles, vaccine adjuvants, photosensitizers, enhancers of immunotherapy) and theranostic (combining both diagnostic and therapeutic), are being fabricated and evaluated. This roadmap covers contributions from experts in these topics summarizing their view of the current status and challenges, as well as expected advancements in technology to address these challenges.

KW - immunotherapy

KW - metal nanoparticles

KW - modeling

KW - nanoparticle imaging

KW - radiotherapy

KW - theranostics

KW - therapeutic applications of nanoparticles

UR - http://www.scopus.com/inward/record.url?scp=85088559395&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85088559395&partnerID=8YFLogxK

U2 - 10.1088/1361-6560/ab9159

DO - 10.1088/1361-6560/ab9159

M3 - Article

C2 - 32380492

AN - SCOPUS:85088559395

SN - 0031-9155

VL - 65

JO - Physics in medicine and biology

JF - Physics in medicine and biology

IS - 21

M1 - 21RM02

ER -

Roadmap for metal nanoparticles in radiation therapy: Current status, translational challenges, and future directions

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this