TY - JOUR
T1 - Role of Epithelial-to-Mesenchymal Transition in Inflammatory Bowel Disease
AU - Lovisa, Sara
AU - Genovese, Giannicola
AU - Danese, Silvio
N1 - Funding Information:
Research work in the laboratory of S.D. is supported by Associazione Italiana Ricerca sul Cancro [AIRC]. Research work in the laboratory of G.G. is supported by the Cancer Prevention Research Institute of Texas [CPRIT].
Publisher Copyright:
© 2018 European Crohn's and Colitis Organisation (ECCO). Published by Oxford University Press. All rights reserved.
PY - 2019/5/1
Y1 - 2019/5/1
N2 - Intestinal fibrosis is an inevitable complication in patients with inflammatory bowel disease [IBD], occurring in its two major clinical manifestations: Ulcerative colitis and Crohn's disease. Fibrosis represents the final outcome of the host reaction to persistent inflammation, which triggers a prolonged wound healing response resulting in the excessive deposition of extracellular matrix, eventually leading to intestinal dysfunction. The process of epithelial-to-mesenchymal transition [EMT] represents an embryonic program relaunched during wound healing, fibrosis and cancer. Here we discuss the initial observations and the most recent findings highlighting the role of EMT in IBD-associated intestinal fibrosis and fistulae formation. In addition, we briefly review knowledge on the cognate process of endothelial-to-mesenchymal transition [EndMT]. Understanding EMT functionality and the molecular mechanisms underlying the activation of this mesenchymal programme will permit designing new therapeutic strategies to halt the fibrogenic response in the intestine.
AB - Intestinal fibrosis is an inevitable complication in patients with inflammatory bowel disease [IBD], occurring in its two major clinical manifestations: Ulcerative colitis and Crohn's disease. Fibrosis represents the final outcome of the host reaction to persistent inflammation, which triggers a prolonged wound healing response resulting in the excessive deposition of extracellular matrix, eventually leading to intestinal dysfunction. The process of epithelial-to-mesenchymal transition [EMT] represents an embryonic program relaunched during wound healing, fibrosis and cancer. Here we discuss the initial observations and the most recent findings highlighting the role of EMT in IBD-associated intestinal fibrosis and fistulae formation. In addition, we briefly review knowledge on the cognate process of endothelial-to-mesenchymal transition [EndMT]. Understanding EMT functionality and the molecular mechanisms underlying the activation of this mesenchymal programme will permit designing new therapeutic strategies to halt the fibrogenic response in the intestine.
KW - Crohn's disease
KW - EMT
KW - EndMT
KW - epithelial-to-mesenchymal transition
KW - inflammatory bowel disease
KW - intestinal fibrosis
KW - ulcerative colitis
UR - http://www.scopus.com/inward/record.url?scp=85068494359&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85068494359&partnerID=8YFLogxK
U2 - 10.1093/ecco-jcc/jjy201
DO - 10.1093/ecco-jcc/jjy201
M3 - Review article
C2 - 30520951
AN - SCOPUS:85068494359
SN - 1873-9946
VL - 13
SP - 659
EP - 668
JO - Journal of Crohn's and Colitis
JF - Journal of Crohn's and Colitis
IS - 5
ER -