@inbook{850195a6bd584099bea71911d77aa988,
title = " Role of GABA B receptors in autonomic control of systemic blood pressure ",
abstract = " GABA B receptors belong to family III G protein-coupled receptors (GPCRs) and are widely distributed in the peripheral and central nervous systems. The GABA B receptor is one of the most important therapeutic targets in the treatment for spasticity. GABA B agonists, such as baclofen, are used as muscle relaxants clinically and are effective for the treatment of anxiety, depression, epilepsy, and cognitive disorders (Caddick \& Hosford, 1996; Dichter, 1997; Enna \& Bowery, 1997). In addition, GABA B receptors regulate neurotransmitter release and neuronal excitability in the brain regions involved in the autonomic nervous system. Recent studies have led to a better understanding of the role of GABA B in the regulation of the autonomic nervous system, especially in disease conditions such as hypertension. Here, we provide an overview of the recent progress, a discussion of disparate and contradictory findings, and a description of theories used to explain various cardiovascular effects of GABA B receptor drugs. Particular emphasis is placed on the role of GABA B receptors in the neural plasticity of brain regions related to the control of sympathetic outflow in cardiovascular disorders.",
keywords = "Brainstem, Hypertension, Hypothalamus, Sympathetic nervous system",
author = "Li, \{De Pei\} and Pan, \{Hui Lin\}",
note = "Funding Information: Work conducted in the authors{\textquoteright} laboratory was supported by grants GM64830 and NS45602 from the National Institutes of Health. ",
year = "2010",
doi = "10.1016/S1054-3589(10)58011-6",
language = "English (US)",
series = "Advances in Pharmacology",
publisher = "Academic Press Inc.",
number = "C",
pages = "257--286",
booktitle = "Advances in Pharmacology",
edition = "C",
}