Role of innate immunity in chemotherapy-induced peripheral neuropathy

Megan L. Uhelski; Yan Li; Miriam M. Fonseca; E. Alfonso Romero-Snadoval; Patrick M. Dougherty

doi:10.1016/j.neulet.2021.135941

Role of innate immunity in chemotherapy-induced peripheral neuropathy

Megan L. Uhelski, Yan Li, Miriam M. Fonseca, E. Alfonso Romero-Snadoval, Patrick M. Dougherty

Pain Medicine

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

It has become increasingly clear that the innate immune system plays an essential role in the generation of many types of neuropathic pain including that which accompanies cancer treatment. In this article we review current findings of the role of the innate immune system in contributing to cancer treatment pain at the distal endings of peripheral nerve, in the nerve trunk, in the dorsal root ganglion and in the spinal dorsal horn.

Original language	English (US)
Article number	135941
Journal	Neuroscience Letters
Volume	755
DOIs	https://doi.org/10.1016/j.neulet.2021.135941
State	Published - Jun 11 2021

Keywords

Bortezomib
Macrophage
Oxaliplatin
Paclitaxel
TLR4

ASJC Scopus subject areas

General Neuroscience

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10.1016/j.neulet.2021.135941

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title = "Role of innate immunity in chemotherapy-induced peripheral neuropathy",

abstract = "It has become increasingly clear that the innate immune system plays an essential role in the generation of many types of neuropathic pain including that which accompanies cancer treatment. In this article we review current findings of the role of the innate immune system in contributing to cancer treatment pain at the distal endings of peripheral nerve, in the nerve trunk, in the dorsal root ganglion and in the spinal dorsal horn.",

keywords = "Bortezomib, Macrophage, Oxaliplatin, Paclitaxel, TLR4",

author = "Uhelski, {Megan L.} and Yan Li and Fonseca, {Miriam M.} and Romero-Snadoval, {E. Alfonso} and Dougherty, {Patrick M.}",

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AU - Li, Yan

AU - Fonseca, Miriam M.

AU - Romero-Snadoval, E. Alfonso

AU - Dougherty, Patrick M.

PY - 2021/6/11

Y1 - 2021/6/11

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AB - It has become increasingly clear that the innate immune system plays an essential role in the generation of many types of neuropathic pain including that which accompanies cancer treatment. In this article we review current findings of the role of the innate immune system in contributing to cancer treatment pain at the distal endings of peripheral nerve, in the nerve trunk, in the dorsal root ganglion and in the spinal dorsal horn.

KW - Bortezomib

KW - Macrophage

KW - Oxaliplatin

KW - Paclitaxel

KW - TLR4

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JO - Neuroscience Letters

JF - Neuroscience Letters

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Role of innate immunity in chemotherapy-induced peripheral neuropathy

Abstract

Keywords

ASJC Scopus subject areas

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