TY - JOUR
T1 - Role of nuclear factor-kB-mediated inflammatory pathways in cancer-related symptoms and their regulation by nutritional agents
AU - Gupta, Subash C.
AU - Kim, Ji Hye
AU - Kannappan, Ramaswamy
AU - Reuter, Simone
AU - Dougherty, Patrick M.
AU - Aggarwal, Bharat B.
N1 - Funding Information:
We thank Michael Worley and the Department of Scientific Publications for carefully editing the manuscript and providing valuable comments. Dr Aggarwal is the Ransom Horne, Jr, Professor of Cancer Research. This work was supported by a core grant from the National Institutes of Health (CA-16 672), a program project grant from the National Institutes of Health (NIH CA-124787-01A2), and a grant from the Center for Targeted Therapy of MD Anderson Cancer Center.
PY - 2011/6
Y1 - 2011/6
N2 - Cancer is a disease characterized by dysregulation of multiple genes and is associated with symptoms such as cachexia, anorexia, fatigue, depression, neuropathic pain, anxiety, cognitive impairment, sleep disorders and delirium (acute confusion state) in medically ill patients. These symptoms are caused by either the cancer itself or the cancer treatment. During the past decade, increasing evidence has shown that the dysregulation of inflammatory pathways contributes to the expression of these symptoms. Cancer patients have been found to have higher levels of proinflammatory cytokines such as interleukin-6. The nuclear factor (NF)-kB is a major mediator of inflammatory pathways. Therefore, anti-inflammatory agents that can modulate the NF-kB activation and inflammatory pathways may have potential in improving cancer-related symptoms in patients. Because of their multitargeting properties, low cost, low toxicity and immediate availability, natural agents have gained considerable attention for prevention and treatment of cancer-related symptoms. How NF-kB and inflammatory pathways contribute to cancer-related symptoms is the focus of this review. We will also discuss how nutritional agents such as curcumin, genistein, resveratrol, epigallocatechin gallate and lycopene can modulate inflammatory pathways and thereby reduce cancer-related symptoms in patients.
AB - Cancer is a disease characterized by dysregulation of multiple genes and is associated with symptoms such as cachexia, anorexia, fatigue, depression, neuropathic pain, anxiety, cognitive impairment, sleep disorders and delirium (acute confusion state) in medically ill patients. These symptoms are caused by either the cancer itself or the cancer treatment. During the past decade, increasing evidence has shown that the dysregulation of inflammatory pathways contributes to the expression of these symptoms. Cancer patients have been found to have higher levels of proinflammatory cytokines such as interleukin-6. The nuclear factor (NF)-kB is a major mediator of inflammatory pathways. Therefore, anti-inflammatory agents that can modulate the NF-kB activation and inflammatory pathways may have potential in improving cancer-related symptoms in patients. Because of their multitargeting properties, low cost, low toxicity and immediate availability, natural agents have gained considerable attention for prevention and treatment of cancer-related symptoms. How NF-kB and inflammatory pathways contribute to cancer-related symptoms is the focus of this review. We will also discuss how nutritional agents such as curcumin, genistein, resveratrol, epigallocatechin gallate and lycopene can modulate inflammatory pathways and thereby reduce cancer-related symptoms in patients.
KW - Cancer-related symptoms
KW - Cytokines
KW - Inflammation
KW - NF-kB
KW - Nutraceuticals
UR - http://www.scopus.com/inward/record.url?scp=79958848355&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79958848355&partnerID=8YFLogxK
U2 - 10.1258/ebm.2011.011028
DO - 10.1258/ebm.2011.011028
M3 - Review article
C2 - 21565893
AN - SCOPUS:79958848355
SN - 1535-3702
VL - 236
SP - 658
EP - 671
JO - Experimental Biology and Medicine
JF - Experimental Biology and Medicine
IS - 6
ER -