Royal jelly inhibited N-acetylation and metabolism of 2-aminofluorene in human liver tumor cells (J5)

Chun S. Yu, Feng T. Yeh, Fu S. Yu, Kwong C. Cheng, Jing G. Chung

    Research output: Contribution to journalArticle

    2 Scopus citations

    Abstract

    The present study was carried out to evaluate the question of whether or not royal jelly affects N-acetylation and metabolism of 2-aminofluorene (2-AF) in the human liver tumor cell line (J 5). N-acetylation and metabolism of 2-AF in intact J5 cells was determined by using high performance liquid chromatography for the amounts of acetylated and nonacetylated 2-AF and profile of 2-AF metabolism. The results indicated that royal jelly displayed a dose-dependent inhibition of N-acetylation of 2-AF in J5 cells. Royal jelly also decreased the profile of 2-AF metabolites in J5 cells. This report is the first demonstration which showed that royal jelly affects N-acetylation of 2-AF in human liver tumor cells (J5).

    Original languageEnglish (US)
    Pages (from-to)83-90
    Number of pages8
    JournalToxicological and Environmental Chemistry
    Volume87
    Issue number1
    DOIs
    StatePublished - Jan 1 2005

    Keywords

    • Arylamine (N-acetyl-2-aminofluorene and 2-aminofluorene)
    • Liver tumor cells
    • N-acetyltransferase
    • Royal jelly

    ASJC Scopus subject areas

    • Environmental Chemistry
    • Pollution
    • Health, Toxicology and Mutagenesis

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