Saeng-Maek-San, a medicinal herb complex, protects liver cell damage induced by alcohol

Kap Joo Park; Min Jung Lee; Hyunmin Kang; Kang Sung Kim; Sang Han Lee; Ikhyun Cho; Hyung Hoan Lee

doi:10.1248/bpb.25.1451

Saeng-Maek-San, a medicinal herb complex, protects liver cell damage induced by alcohol

Kap Joo Park, Min Jung Lee, Hyunmin Kang, Kang Sung Kim, Sang Han Lee, Ikhyun Cho, Hyung Hoan Lee

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

The effect of treatment with Saeng-Maek-San (SMS) Complex (SMS1 or SMS2) upon rat hepatocytes exposed to alcohol was investigated. We compared the serum biochemistry and liver histology of rats administered both alcohol and SMS to control rats treated with alcohol alone. SMS treatment resulted in a significant reduction in the levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and triglycerides (TG) compared to the control rats. In contrast, expression levels of alcohol dehydrogenase (ADH) were increased. Electron microscopy indicated that administration of SMS preserved the structure of organelles, including the nucleus and mitochondria. In addition, lipid droplets and secondary lysosomes were observed in the control rats. These data suggest that SMS represents an excellent candidate for protection of rat hepatocytes from alcohol-mediated damage.

Original language	English (US)
Pages (from-to)	1451-1455
Number of pages	5
Journal	Biological and Pharmaceutical Bulletin
Volume	25
Issue number	11
DOIs	https://doi.org/10.1248/bpb.25.1451
State	Published - Nov 2002
Externally published	Yes

Keywords

Alcohol
Rat liver cell
Saeng-Maek-San

ASJC Scopus subject areas

Pharmacology
Pharmaceutical Science

Access to Document

10.1248/bpb.25.1451

Cite this

@article{8621593cc59f41e9ab89ced00d9067aa,

title = "Saeng-Maek-San, a medicinal herb complex, protects liver cell damage induced by alcohol",

abstract = "The effect of treatment with Saeng-Maek-San (SMS) Complex (SMS1 or SMS2) upon rat hepatocytes exposed to alcohol was investigated. We compared the serum biochemistry and liver histology of rats administered both alcohol and SMS to control rats treated with alcohol alone. SMS treatment resulted in a significant reduction in the levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and triglycerides (TG) compared to the control rats. In contrast, expression levels of alcohol dehydrogenase (ADH) were increased. Electron microscopy indicated that administration of SMS preserved the structure of organelles, including the nucleus and mitochondria. In addition, lipid droplets and secondary lysosomes were observed in the control rats. These data suggest that SMS represents an excellent candidate for protection of rat hepatocytes from alcohol-mediated damage.",

keywords = "Alcohol, Rat liver cell, Saeng-Maek-San",

author = "Park, {Kap Joo} and Lee, {Min Jung} and Hyunmin Kang and Kim, {Kang Sung} and Lee, {Sang Han} and Ikhyun Cho and Lee, {Hyung Hoan}",

year = "2002",

month = nov,

doi = "10.1248/bpb.25.1451",

language = "English (US)",

volume = "25",

pages = "1451--1455",

journal = "Biological and Pharmaceutical Bulletin",

issn = "0918-6158",

publisher = "Pharmaceutical Society of Japan",

number = "11",

}

TY - JOUR

T1 - Saeng-Maek-San, a medicinal herb complex, protects liver cell damage induced by alcohol

AU - Park, Kap Joo

AU - Lee, Min Jung

AU - Kang, Hyunmin

AU - Kim, Kang Sung

AU - Lee, Sang Han

AU - Cho, Ikhyun

AU - Lee, Hyung Hoan

PY - 2002/11

Y1 - 2002/11

N2 - The effect of treatment with Saeng-Maek-San (SMS) Complex (SMS1 or SMS2) upon rat hepatocytes exposed to alcohol was investigated. We compared the serum biochemistry and liver histology of rats administered both alcohol and SMS to control rats treated with alcohol alone. SMS treatment resulted in a significant reduction in the levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and triglycerides (TG) compared to the control rats. In contrast, expression levels of alcohol dehydrogenase (ADH) were increased. Electron microscopy indicated that administration of SMS preserved the structure of organelles, including the nucleus and mitochondria. In addition, lipid droplets and secondary lysosomes were observed in the control rats. These data suggest that SMS represents an excellent candidate for protection of rat hepatocytes from alcohol-mediated damage.

AB - The effect of treatment with Saeng-Maek-San (SMS) Complex (SMS1 or SMS2) upon rat hepatocytes exposed to alcohol was investigated. We compared the serum biochemistry and liver histology of rats administered both alcohol and SMS to control rats treated with alcohol alone. SMS treatment resulted in a significant reduction in the levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and triglycerides (TG) compared to the control rats. In contrast, expression levels of alcohol dehydrogenase (ADH) were increased. Electron microscopy indicated that administration of SMS preserved the structure of organelles, including the nucleus and mitochondria. In addition, lipid droplets and secondary lysosomes were observed in the control rats. These data suggest that SMS represents an excellent candidate for protection of rat hepatocytes from alcohol-mediated damage.

KW - Alcohol

KW - Rat liver cell

KW - Saeng-Maek-San

UR - http://www.scopus.com/inward/record.url?scp=1842869283&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=1842869283&partnerID=8YFLogxK

U2 - 10.1248/bpb.25.1451

DO - 10.1248/bpb.25.1451

M3 - Article

C2 - 12419958

AN - SCOPUS:1842869283

SN - 0918-6158

VL - 25

SP - 1451

EP - 1455

JO - Biological and Pharmaceutical Bulletin

JF - Biological and Pharmaceutical Bulletin

IS - 11

ER -

Saeng-Maek-San, a medicinal herb complex, protects liver cell damage induced by alcohol

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this