TY - JOUR
T1 - Sarcoma molecular testing
T2 - Diagnosis and prognosis
AU - Lazar, Alexander J.F.
AU - Trent, Jonathan C.
PY - 2007/7
Y1 - 2007/7
N2 - Methodologies employed in the rapidly developing field of soft tissue sarcoma molecular testing focus primarily on diagnosis using chromosomal translocations and the resulting fusion transcripts. Molecular prognostic testing holds promise in this complex group of rare mesenchymal malignancies, but results are preliminary and require further confirmation. Analysis of activating KIT mutations in gastrointestinal stromal tumors is currently being used in management of patient therapy.
AB - Methodologies employed in the rapidly developing field of soft tissue sarcoma molecular testing focus primarily on diagnosis using chromosomal translocations and the resulting fusion transcripts. Molecular prognostic testing holds promise in this complex group of rare mesenchymal malignancies, but results are preliminary and require further confirmation. Analysis of activating KIT mutations in gastrointestinal stromal tumors is currently being used in management of patient therapy.
UR - http://www.scopus.com/inward/record.url?scp=34447311963&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34447311963&partnerID=8YFLogxK
U2 - 10.1007/s11912-007-0038-8
DO - 10.1007/s11912-007-0038-8
M3 - Review article
C2 - 17588356
AN - SCOPUS:34447311963
SN - 1523-3790
VL - 9
SP - 309
EP - 315
JO - Current oncology reports
JF - Current oncology reports
IS - 4
ER -