Scissors for autolysosome tubules

Yang Chen; Li Yu

doi:10.15252/embj.201592519

Scissors for autolysosome tubules

Yang Chen, Li Yu

Research output: Contribution to journal › Short survey › peer-review

5 Scopus citations

Abstract

Autophagic lysosome reformation (ALR) is a cellular process in which lysosomes are reformed through scission of proto-lysosomes from tubular structures extruded from autolysosomes. Despite recent progress, the molecular mechanism of ALR is far from clear. A paper in this issue of The EMBO Journal has identified lysosome-localized PI(3)P, which is generated by the VPS34-UVRAG complex in an mTOR-dependent manner, as an important regulator of autolysosome tubule scission (Munson et al,). At the end of the autophagic process, lysosomes need to reform via autophagic lysosome reformation. Phospholipid PI(3)P aids in this process downstream of mTOR and VPS34-UVRAG activity.

Original language	English (US)
Pages (from-to)	2217-2218
Number of pages	2
Journal	EMBO Journal
Volume	34
Issue number	17
DOIs	https://doi.org/10.15252/embj.201592519
State	Published - Sep 2 2015
Externally published	Yes

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
General Biochemistry, Genetics and Molecular Biology
General Immunology and Microbiology

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title = "Scissors for autolysosome tubules",

abstract = "Autophagic lysosome reformation (ALR) is a cellular process in which lysosomes are reformed through scission of proto-lysosomes from tubular structures extruded from autolysosomes. Despite recent progress, the molecular mechanism of ALR is far from clear. A paper in this issue of The EMBO Journal has identified lysosome-localized PI(3)P, which is generated by the VPS34-UVRAG complex in an mTOR-dependent manner, as an important regulator of autolysosome tubule scission (Munson et al,). At the end of the autophagic process, lysosomes need to reform via autophagic lysosome reformation. Phospholipid PI(3)P aids in this process downstream of mTOR and VPS34-UVRAG activity.",

author = "Yang Chen and Li Yu",

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year = "2015",

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doi = "10.15252/embj.201592519",

language = "English (US)",

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T1 - Scissors for autolysosome tubules

AU - Chen, Yang

AU - Yu, Li

PY - 2015/9/2

Y1 - 2015/9/2

N2 - Autophagic lysosome reformation (ALR) is a cellular process in which lysosomes are reformed through scission of proto-lysosomes from tubular structures extruded from autolysosomes. Despite recent progress, the molecular mechanism of ALR is far from clear. A paper in this issue of The EMBO Journal has identified lysosome-localized PI(3)P, which is generated by the VPS34-UVRAG complex in an mTOR-dependent manner, as an important regulator of autolysosome tubule scission (Munson et al,). At the end of the autophagic process, lysosomes need to reform via autophagic lysosome reformation. Phospholipid PI(3)P aids in this process downstream of mTOR and VPS34-UVRAG activity.

AB - Autophagic lysosome reformation (ALR) is a cellular process in which lysosomes are reformed through scission of proto-lysosomes from tubular structures extruded from autolysosomes. Despite recent progress, the molecular mechanism of ALR is far from clear. A paper in this issue of The EMBO Journal has identified lysosome-localized PI(3)P, which is generated by the VPS34-UVRAG complex in an mTOR-dependent manner, as an important regulator of autolysosome tubule scission (Munson et al,). At the end of the autophagic process, lysosomes need to reform via autophagic lysosome reformation. Phospholipid PI(3)P aids in this process downstream of mTOR and VPS34-UVRAG activity.

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DO - 10.15252/embj.201592519

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SP - 2217

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JO - EMBO Journal

JF - EMBO Journal

IS - 17

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Scissors for autolysosome tubules

Abstract

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