Sclerosing orbital pseudotumor with involvement of the optic nerve

Hesham M. Amin, Jay I. Perilman, Troy W. Close, Sharon L. Collins, Chinnamma Thomas

Research output: Contribution to journalArticlepeer-review

Abstract

A 34-year-old, African-American woman presented with severe left orbital pain and headaches, associated with gradual, progressive loss of vision. Computerized tomography scanning showed infiltration of the retrobulbar tissue and surrounding soft tissue by a diffuse, ill-defined mass. A biopsy of the mass was diagnosed as inflammatory pseudotumor. Subsequently, the patient received corticosteroids, cytotoxic agents, and radiation therapy without noticeable improvement. She then underwent left orbital exenteration for pain resistant to narcotic analgesia. Histopathologic evaluation of the lesion demonstrated focal polymorphous inflammatory infiltrate in a background of extensive, diffuse sclerotic tissue. The optic nerve, sinus bone, and cartilage were infiltrated by a similar process. The clinical presentation and histopathologic criteria established a diagnosis of sclerosing orbital pseudotumor. Such a lesion represents a unique, clinicopathologic variant of inflammatory orbital pseudotumors. The patient is currently asymptomatic without evidence of recurrence one year after the surgery.

Original languageEnglish (US)
Pages (from-to)194-200
Number of pages7
JournalClinical and Surgical Ophthalmology
Volume29
Issue number8-9
StatePublished - Aug 2011
Externally publishedYes

ASJC Scopus subject areas

  • Surgery
  • Ophthalmology

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