Secretion and extracellular space travel of Wnt proteins

Julia Christina Gross, Michael Boutros

Research output: Contribution to journalReview article

36 Citations (Scopus)

Abstract

Wnt signaling pathways control many processes during development, stem cell maintenance and homeostasis, and their aberrant regulation has been linked to diseases in man including diabetes, neurodegeneration and cancer. Wnts are hydrophobic proteins, however, quite paradoxically, they can travel over distances to induce cell-type specific responses. While there has been an initial focus on elucidating the intracellular signaling cascade, discoveries in the past few years have shed light on a highly complex, and regulated secretory process that guides Wnt proteins through the exocytic pathway. Wnt proteins are at least in portion packaged onto extracellular carriers such as exosomes. Similar to dysregulation of components in the Wnt receiving cell, failure to regulate Wnt secretion has been linked to cancer. Here, we review recent discoveries on factors and processes implicated in Wnt secretion.

Original languageEnglish (US)
Pages (from-to)385-390
Number of pages6
JournalCurrent Opinion in Genetics and Development
Volume23
Issue number4
DOIs
StatePublished - Aug 1 2013

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Wnt Proteins
Extracellular Space
Exosomes
Wnt Signaling Pathway
Secretory Pathway
Neoplasms
Homeostasis
Stem Cells
Maintenance
Proteins

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

Cite this

Secretion and extracellular space travel of Wnt proteins. / Gross, Julia Christina; Boutros, Michael.

In: Current Opinion in Genetics and Development, Vol. 23, No. 4, 01.08.2013, p. 385-390.

Research output: Contribution to journalReview article

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