Sentinel node biopsy in patients with cutaneous melanoma of the head and neck: Recurrence and survival study

Fernando Gomez-Rivera; Alfredo Santillan; Andrea Barber McMurphey; George Paraskevopoulos; Dianna B. Roberts; Victor G. Prieto; Jeffrey N. Myers

doi:10.1002/hed.20875

Sentinel node biopsy in patients with cutaneous melanoma of the head and neck: Recurrence and survival study

Fernando Gomez-Rivera, Alfredo Santillan, Andrea Barber McMurphey, George Paraskevopoulos, Dianna B. Roberts, Victor G. Prieto, Jeffrey N. Myers

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57 Scopus citations

Abstract

Background. Controversy remains regarding the benefits of sentinel lymph node (SLN) biopsy for predicting survival in cutaneous melanoma of the head and neck (CMHN). Methods. We analyzed the factors associated with the recurrence and survival of CMHN patients treated in our institution. Results. One hundred thirteen patients underwent SLN biopsy for CMHN in a 12-year period. SLN identification was successful in 96%, with a median of 3 SLNs per patient. Positive-SLNs were identified in 21%. With a median follow-up of 34 months, 28% recurred. Disease-free survival (DFS) and overall survival (OS) rates were 66%and 78%in patients with SLN-negative, and 39% and 62% in SLN-positive disease. In multivariate analysis, greater Breslow-thickness was associated with decreased DFS rate (HR 2.07, CI 1.04-4.09), and age >60 years (HR 3.53, CI 1.32-9.4) with lower 5-year OS rate. Conclusion. Primary tumor thickness and age were associated with decreased survival, whereas SLN status showed a trend for prognostic significance in CMHN.

Original language	English (US)
Pages (from-to)	1284-1294
Number of pages	11
Journal	Head and Neck
Volume	30
Issue number	10
DOIs	https://doi.org/10.1002/hed.20875
State	Published - Oct 2008

Keywords

Biopsy
Head
Lymphoscintigraphy
Melanoma
Neck
Sentinel node

ASJC Scopus subject areas

Otorhinolaryngology

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10.1002/hed.20875

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@article{2edaceede8354306a1dc3ffe6ad7fa65,

title = "Sentinel node biopsy in patients with cutaneous melanoma of the head and neck: Recurrence and survival study",

abstract = "Background. Controversy remains regarding the benefits of sentinel lymph node (SLN) biopsy for predicting survival in cutaneous melanoma of the head and neck (CMHN). Methods. We analyzed the factors associated with the recurrence and survival of CMHN patients treated in our institution. Results. One hundred thirteen patients underwent SLN biopsy for CMHN in a 12-year period. SLN identification was successful in 96%, with a median of 3 SLNs per patient. Positive-SLNs were identified in 21%. With a median follow-up of 34 months, 28% recurred. Disease-free survival (DFS) and overall survival (OS) rates were 66%and 78%in patients with SLN-negative, and 39% and 62% in SLN-positive disease. In multivariate analysis, greater Breslow-thickness was associated with decreased DFS rate (HR 2.07, CI 1.04-4.09), and age >60 years (HR 3.53, CI 1.32-9.4) with lower 5-year OS rate. Conclusion. Primary tumor thickness and age were associated with decreased survival, whereas SLN status showed a trend for prognostic significance in CMHN.",

keywords = "Biopsy, Head, Lymphoscintigraphy, Melanoma, Neck, Sentinel node",

author = "Fernando Gomez-Rivera and Alfredo Santillan and McMurphey, {Andrea Barber} and George Paraskevopoulos and Roberts, {Dianna B.} and Prieto, {Victor G.} and Myers, {Jeffrey N.}",

year = "2008",

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doi = "10.1002/hed.20875",

language = "English (US)",

volume = "30",

pages = "1284--1294",

journal = "Head and Neck",

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TY - JOUR

T1 - Sentinel node biopsy in patients with cutaneous melanoma of the head and neck

T2 - Recurrence and survival study

AU - Gomez-Rivera, Fernando

AU - Santillan, Alfredo

AU - McMurphey, Andrea Barber

AU - Paraskevopoulos, George

AU - Roberts, Dianna B.

AU - Prieto, Victor G.

AU - Myers, Jeffrey N.

PY - 2008/10

Y1 - 2008/10

N2 - Background. Controversy remains regarding the benefits of sentinel lymph node (SLN) biopsy for predicting survival in cutaneous melanoma of the head and neck (CMHN). Methods. We analyzed the factors associated with the recurrence and survival of CMHN patients treated in our institution. Results. One hundred thirteen patients underwent SLN biopsy for CMHN in a 12-year period. SLN identification was successful in 96%, with a median of 3 SLNs per patient. Positive-SLNs were identified in 21%. With a median follow-up of 34 months, 28% recurred. Disease-free survival (DFS) and overall survival (OS) rates were 66%and 78%in patients with SLN-negative, and 39% and 62% in SLN-positive disease. In multivariate analysis, greater Breslow-thickness was associated with decreased DFS rate (HR 2.07, CI 1.04-4.09), and age >60 years (HR 3.53, CI 1.32-9.4) with lower 5-year OS rate. Conclusion. Primary tumor thickness and age were associated with decreased survival, whereas SLN status showed a trend for prognostic significance in CMHN.

AB - Background. Controversy remains regarding the benefits of sentinel lymph node (SLN) biopsy for predicting survival in cutaneous melanoma of the head and neck (CMHN). Methods. We analyzed the factors associated with the recurrence and survival of CMHN patients treated in our institution. Results. One hundred thirteen patients underwent SLN biopsy for CMHN in a 12-year period. SLN identification was successful in 96%, with a median of 3 SLNs per patient. Positive-SLNs were identified in 21%. With a median follow-up of 34 months, 28% recurred. Disease-free survival (DFS) and overall survival (OS) rates were 66%and 78%in patients with SLN-negative, and 39% and 62% in SLN-positive disease. In multivariate analysis, greater Breslow-thickness was associated with decreased DFS rate (HR 2.07, CI 1.04-4.09), and age >60 years (HR 3.53, CI 1.32-9.4) with lower 5-year OS rate. Conclusion. Primary tumor thickness and age were associated with decreased survival, whereas SLN status showed a trend for prognostic significance in CMHN.

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KW - Lymphoscintigraphy

KW - Melanoma

KW - Neck

KW - Sentinel node

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Sentinel node biopsy in patients with cutaneous melanoma of the head and neck: Recurrence and survival study

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