Serum and tissue vascular endothelial growth factor predicts prognosis in hepatocellular carcinoma patients after partial liver resection

Chong Zhong, Wei Wei, Xiao Kang Su, Hui Dong Li, Fa Bing Xu, Rong Ping Guo

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Background/Aims: To explore the effect of vascular endothelial growth factor (VEGF) expression on prognosis of hepatocellular carcinoma (HCC) after partial liver resection. Methodology: The expression of VEGF in 64 preoperative serum and resection specimens of HCC, confirmed by pathology, was detected by enzyme-linked immunosorbent assay (ELISA) and immunohistochemistry. Correlations of VEGF level to clinicopathological features were analyzed. Cox regression model was used to analyze the recurrence risk factors after hepatectomy. Results: Serum level of VEGF in HCC patients was 334.50±247.62pg/mL, significantly higher than healthy control group (p<0.01); it was also significantly higher in recurrent group than in non-recurrent group (p<0.05). VEGF was expressed in cytoplasm of HCC specimens. The positive rates of VEGF was significantly higher in recurrent group than in non-recurrent group (85.0% vs. 54.5%, p<0.05). The 1-, 2- and 3-year disease-free survival rates were significantly higher in VEGF(-) group than in VEGF(+) group (81.3% vs. 52.2%, 68.8% vs. 33.3%, and 62.5% vs. 29.1%, p<0.01). The overall survival rates of VEGF(-) subgroup was borderline significant higher than that of VEGF(+) subgroup (p=0.068). Multivariate analysis revealed that preoperative macroscopically disseminated nodules, tumor micrometastasis, serum and tissue VEGF level were independent recurrence risk factors. Conclusions: Serum and tissue VEGF level of HCC patients ascends distinctly, correlates to the recurrence of HCC after partial liver resection which can be used to estimate the risk of postoperative recurrence of HCC.

Original languageEnglish (US)
Pages (from-to)93-97
Number of pages5
JournalHepato-gastroenterology
Volume59
Issue number113
DOIs
StatePublished - Jan 1 2012

Fingerprint

Vascular Endothelial Growth Factor A
Hepatocellular Carcinoma
Liver
Serum
Recurrence
Survival Rate
Neoplasm Micrometastasis
Hepatectomy
Proportional Hazards Models
Disease-Free Survival
Cytoplasm
Multivariate Analysis
Enzyme-Linked Immunosorbent Assay
Immunohistochemistry
Pathology
Control Groups

Keywords

  • Enzyme-linked immunosorbent assay
  • Hepatocellular carcinoma
  • Immunohistochemistry
  • Recurrence
  • VEGF

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

Cite this

Serum and tissue vascular endothelial growth factor predicts prognosis in hepatocellular carcinoma patients after partial liver resection. / Zhong, Chong; Wei, Wei; Su, Xiao Kang; Li, Hui Dong; Xu, Fa Bing; Guo, Rong Ping.

In: Hepato-gastroenterology, Vol. 59, No. 113, 01.01.2012, p. 93-97.

Research output: Contribution to journalArticle

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abstract = "Background/Aims: To explore the effect of vascular endothelial growth factor (VEGF) expression on prognosis of hepatocellular carcinoma (HCC) after partial liver resection. Methodology: The expression of VEGF in 64 preoperative serum and resection specimens of HCC, confirmed by pathology, was detected by enzyme-linked immunosorbent assay (ELISA) and immunohistochemistry. Correlations of VEGF level to clinicopathological features were analyzed. Cox regression model was used to analyze the recurrence risk factors after hepatectomy. Results: Serum level of VEGF in HCC patients was 334.50±247.62pg/mL, significantly higher than healthy control group (p<0.01); it was also significantly higher in recurrent group than in non-recurrent group (p<0.05). VEGF was expressed in cytoplasm of HCC specimens. The positive rates of VEGF was significantly higher in recurrent group than in non-recurrent group (85.0{\%} vs. 54.5{\%}, p<0.05). The 1-, 2- and 3-year disease-free survival rates were significantly higher in VEGF(-) group than in VEGF(+) group (81.3{\%} vs. 52.2{\%}, 68.8{\%} vs. 33.3{\%}, and 62.5{\%} vs. 29.1{\%}, p<0.01). The overall survival rates of VEGF(-) subgroup was borderline significant higher than that of VEGF(+) subgroup (p=0.068). Multivariate analysis revealed that preoperative macroscopically disseminated nodules, tumor micrometastasis, serum and tissue VEGF level were independent recurrence risk factors. Conclusions: Serum and tissue VEGF level of HCC patients ascends distinctly, correlates to the recurrence of HCC after partial liver resection which can be used to estimate the risk of postoperative recurrence of HCC.",
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