血清载脂蛋白B与中国中老年人代谢综合征风险增加相关:一项横断面和前瞻性队列研究

Translated title of the contribution: Serum apolipoprotein B is associated with increased risk of metabolic syndrome among middle-aged and elderly Chinese: A cross-sectional and prospective cohort study

Rui Du, Xueyan Wu, Kui Peng, Lin Lin, Mian Li, Yu Xu, Min Xu, Yuhong Chen, Donghui Li, Jieli Lu, Yufang Bi, Weiqing Wang, Guang Ning

Research output: Contribution to journalArticle

Abstract

Background: Serum apolipoprotein (apo) B has been associated with an increased risk of atherosclerotic cardiovascular diseases. However, findings on the association between apoB and the risk of metabolic syndrome (MetS) are inconsistent. The purpose of this study was to investigate the association between serum apoB and MetS risk in Chinese population. Methods: A baseline survey was conducted in a population-based cohort of 10 340 adults aged ≥40 years in Shanghai, China, in 2010. A follow-up visit was conducted to assess incident diabetes in 2015. Results: At baseline, 2794 of 10 340 participants (27.02%) had MetS. Serum apoB was significantly associated with an increased risk of prevalent MetS. Multivariable-adjusted odds ratios and 95% confidence intervals (CIs) for quintiles 2-5 compared with quintile 1 (reference) were 1.29 (1.02-1.63), 1.47 (1.18-1.84), 1.32 (1.06-1.65), and 2.02 (1.61-2.51), respectively (Ptrend < 0.05). During an average of 5.1 years follow-up, 4627 individuals without MetS at baseline showed a significant association between apoB and the risk of incident MetS. Multivariable-adjusted risk ratios (95% CIs) for subjects in apoB quintiles 2-5 compared with the reference were 1.43 (1.13-1.82), 1.57 (1.25-1.98), 1.74 (1.38-2.18), and 2.07 (1.66-2.58), respectively (Ptrend < 0.05). Stratified analysis suggested that the above association was much stronger among normal weight individuals than in those who were overweight or obese. Conclusion: These cross-sectional and prospective studies provide evidence that serum apoB is associated with existing MetS and is a possible predictor of the risk of MetS, especially among normal weight individuals.

Original languageChinese
Pages (from-to)752-760
Number of pages9
JournalJournal of Diabetes
Volume11
Issue number9
DOIs
StatePublished - Jan 1 2019

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Apolipoproteins B
Cohort Studies
Prospective Studies
Serum
Odds Ratio
Confidence Intervals
Weights and Measures
Population
China
Cardiovascular Diseases
Cross-Sectional Studies

Keywords

  • apolipoprotein B
  • lipids
  • lipoprotein
  • metabolic syndrome
  • risk

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

Cite this

血清载脂蛋白B与中国中老年人代谢综合征风险增加相关:一项横断面和前瞻性队列研究. / Du, Rui; Wu, Xueyan; Peng, Kui; Lin, Lin; Li, Mian; Xu, Yu; Xu, Min; Chen, Yuhong; Li, Donghui; Lu, Jieli; Bi, Yufang; Wang, Weiqing; Ning, Guang.

In: Journal of Diabetes, Vol. 11, No. 9, 01.01.2019, p. 752-760.

Research output: Contribution to journalArticle

Du, R, Wu, X, Peng, K, Lin, L, Li, M, Xu, Y, Xu, M, Chen, Y, Li, D, Lu, J, Bi, Y, Wang, W & Ning, G 2019, '血清载脂蛋白B与中国中老年人代谢综合征风险增加相关:一项横断面和前瞻性队列研究', Journal of Diabetes, vol. 11, no. 9, pp. 752-760. https://doi.org/10.1111/1753-0407.12904
Du, Rui ; Wu, Xueyan ; Peng, Kui ; Lin, Lin ; Li, Mian ; Xu, Yu ; Xu, Min ; Chen, Yuhong ; Li, Donghui ; Lu, Jieli ; Bi, Yufang ; Wang, Weiqing ; Ning, Guang. / 血清载脂蛋白B与中国中老年人代谢综合征风险增加相关:一项横断面和前瞻性队列研究. In: Journal of Diabetes. 2019 ; Vol. 11, No. 9. pp. 752-760.
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abstract = "Background: Serum apolipoprotein (apo) B has been associated with an increased risk of atherosclerotic cardiovascular diseases. However, findings on the association between apoB and the risk of metabolic syndrome (MetS) are inconsistent. The purpose of this study was to investigate the association between serum apoB and MetS risk in Chinese population. Methods: A baseline survey was conducted in a population-based cohort of 10 340 adults aged ≥40 years in Shanghai, China, in 2010. A follow-up visit was conducted to assess incident diabetes in 2015. Results: At baseline, 2794 of 10 340 participants (27.02{\%}) had MetS. Serum apoB was significantly associated with an increased risk of prevalent MetS. Multivariable-adjusted odds ratios and 95{\%} confidence intervals (CIs) for quintiles 2-5 compared with quintile 1 (reference) were 1.29 (1.02-1.63), 1.47 (1.18-1.84), 1.32 (1.06-1.65), and 2.02 (1.61-2.51), respectively (Ptrend < 0.05). During an average of 5.1 years follow-up, 4627 individuals without MetS at baseline showed a significant association between apoB and the risk of incident MetS. Multivariable-adjusted risk ratios (95{\%} CIs) for subjects in apoB quintiles 2-5 compared with the reference were 1.43 (1.13-1.82), 1.57 (1.25-1.98), 1.74 (1.38-2.18), and 2.07 (1.66-2.58), respectively (Ptrend < 0.05). Stratified analysis suggested that the above association was much stronger among normal weight individuals than in those who were overweight or obese. Conclusion: These cross-sectional and prospective studies provide evidence that serum apoB is associated with existing MetS and is a possible predictor of the risk of MetS, especially among normal weight individuals.",
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T1 - 血清载脂蛋白B与中国中老年人代谢综合征风险增加相关:一项横断面和前瞻性队列研究

AU - Du, Rui

AU - Wu, Xueyan

AU - Peng, Kui

AU - Lin, Lin

AU - Li, Mian

AU - Xu, Yu

AU - Xu, Min

AU - Chen, Yuhong

AU - Li, Donghui

AU - Lu, Jieli

AU - Bi, Yufang

AU - Wang, Weiqing

AU - Ning, Guang

PY - 2019/1/1

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N2 - Background: Serum apolipoprotein (apo) B has been associated with an increased risk of atherosclerotic cardiovascular diseases. However, findings on the association between apoB and the risk of metabolic syndrome (MetS) are inconsistent. The purpose of this study was to investigate the association between serum apoB and MetS risk in Chinese population. Methods: A baseline survey was conducted in a population-based cohort of 10 340 adults aged ≥40 years in Shanghai, China, in 2010. A follow-up visit was conducted to assess incident diabetes in 2015. Results: At baseline, 2794 of 10 340 participants (27.02%) had MetS. Serum apoB was significantly associated with an increased risk of prevalent MetS. Multivariable-adjusted odds ratios and 95% confidence intervals (CIs) for quintiles 2-5 compared with quintile 1 (reference) were 1.29 (1.02-1.63), 1.47 (1.18-1.84), 1.32 (1.06-1.65), and 2.02 (1.61-2.51), respectively (Ptrend < 0.05). During an average of 5.1 years follow-up, 4627 individuals without MetS at baseline showed a significant association between apoB and the risk of incident MetS. Multivariable-adjusted risk ratios (95% CIs) for subjects in apoB quintiles 2-5 compared with the reference were 1.43 (1.13-1.82), 1.57 (1.25-1.98), 1.74 (1.38-2.18), and 2.07 (1.66-2.58), respectively (Ptrend < 0.05). Stratified analysis suggested that the above association was much stronger among normal weight individuals than in those who were overweight or obese. Conclusion: These cross-sectional and prospective studies provide evidence that serum apoB is associated with existing MetS and is a possible predictor of the risk of MetS, especially among normal weight individuals.

AB - Background: Serum apolipoprotein (apo) B has been associated with an increased risk of atherosclerotic cardiovascular diseases. However, findings on the association between apoB and the risk of metabolic syndrome (MetS) are inconsistent. The purpose of this study was to investigate the association between serum apoB and MetS risk in Chinese population. Methods: A baseline survey was conducted in a population-based cohort of 10 340 adults aged ≥40 years in Shanghai, China, in 2010. A follow-up visit was conducted to assess incident diabetes in 2015. Results: At baseline, 2794 of 10 340 participants (27.02%) had MetS. Serum apoB was significantly associated with an increased risk of prevalent MetS. Multivariable-adjusted odds ratios and 95% confidence intervals (CIs) for quintiles 2-5 compared with quintile 1 (reference) were 1.29 (1.02-1.63), 1.47 (1.18-1.84), 1.32 (1.06-1.65), and 2.02 (1.61-2.51), respectively (Ptrend < 0.05). During an average of 5.1 years follow-up, 4627 individuals without MetS at baseline showed a significant association between apoB and the risk of incident MetS. Multivariable-adjusted risk ratios (95% CIs) for subjects in apoB quintiles 2-5 compared with the reference were 1.43 (1.13-1.82), 1.57 (1.25-1.98), 1.74 (1.38-2.18), and 2.07 (1.66-2.58), respectively (Ptrend < 0.05). Stratified analysis suggested that the above association was much stronger among normal weight individuals than in those who were overweight or obese. Conclusion: These cross-sectional and prospective studies provide evidence that serum apoB is associated with existing MetS and is a possible predictor of the risk of MetS, especially among normal weight individuals.

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KW - lipoprotein

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KW - risk

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