TY - JOUR
T1 - Serum CA 19-9 and risk of incident diabetes in middle-aged and elderly Chinese
T2 - a prospective cohort study
AU - Du, Rui
AU - Sun, Wanwan
AU - Lin, Lin
AU - Sun, Jichao
AU - Peng, Kui
AU - Xu, Yu
AU - Xu, Min
AU - Chen, Yuhong
AU - Bi, Yufang
AU - Wang, Weiqing
AU - Li, Donghui
AU - Lu, Jieli
N1 - Publisher Copyright:
© 2016, Springer-Verlag Italia.
PY - 2017/2/1
Y1 - 2017/2/1
N2 - Aims: Carbohydrate antigen (CA) 19-9 is a tumor marker for gastrointestinal and pancreatic cancers. Previous studies found that CA 19-9 was elevated in patients with diabetes, but little is known about its relationship with diabetes risk in prospective studies. Our objective was to evaluate the association between serum CA 19-9 and the risk of incident diabetes in Chinese population. Methods: Data were obtained from a prospective cohort study among 2391 middle-aged and elderly Chinese with a median follow-up of 3.8 years. The measurement for the study outcome was incident diabetes. Results: Compared with individuals in the lowest quartile, those in the highest quartile of CA 19-9 had significantly higher incidence of diabetes (12.54 vs. 8.86%, P = 0.04). In the fully adjusted logistic regression model, compared with the lowest quartile, the highest quartile of CA 19-9 was significantly associated with 58% increased risk of incident diabetes [odds ratio (OR), 95% confidence interval (CI) 1.58, 1.02–2.44]. Stratified analysis suggested that the increased risk was seen only in women (OR, 95% CI 1.96, 1.10–3.48), or participants aged ≥65 (OR, 95% CI 2.32, 1.03–5.19), or those with body mass index ≥24 (OR, 95% CI 2.09, 1.20–3.63), or current nondrinkers (OR, 95% CI 1.79, 1.09–2.92), or those with impaired glucose regulation (IGR) (OR, 95% CI 2.49, 1.33–4.67). Significant interaction was detected between IGR and serum CA 19-9 (P for interaction <0.0001). Conclusions: Serum CA 19-9 is associated with a significantly increased risk of diabetes among the middle-aged and elderly Chinese population. Further investigations are needed to confirm this association and disclose potential mechanisms.
AB - Aims: Carbohydrate antigen (CA) 19-9 is a tumor marker for gastrointestinal and pancreatic cancers. Previous studies found that CA 19-9 was elevated in patients with diabetes, but little is known about its relationship with diabetes risk in prospective studies. Our objective was to evaluate the association between serum CA 19-9 and the risk of incident diabetes in Chinese population. Methods: Data were obtained from a prospective cohort study among 2391 middle-aged and elderly Chinese with a median follow-up of 3.8 years. The measurement for the study outcome was incident diabetes. Results: Compared with individuals in the lowest quartile, those in the highest quartile of CA 19-9 had significantly higher incidence of diabetes (12.54 vs. 8.86%, P = 0.04). In the fully adjusted logistic regression model, compared with the lowest quartile, the highest quartile of CA 19-9 was significantly associated with 58% increased risk of incident diabetes [odds ratio (OR), 95% confidence interval (CI) 1.58, 1.02–2.44]. Stratified analysis suggested that the increased risk was seen only in women (OR, 95% CI 1.96, 1.10–3.48), or participants aged ≥65 (OR, 95% CI 2.32, 1.03–5.19), or those with body mass index ≥24 (OR, 95% CI 2.09, 1.20–3.63), or current nondrinkers (OR, 95% CI 1.79, 1.09–2.92), or those with impaired glucose regulation (IGR) (OR, 95% CI 2.49, 1.33–4.67). Significant interaction was detected between IGR and serum CA 19-9 (P for interaction <0.0001). Conclusions: Serum CA 19-9 is associated with a significantly increased risk of diabetes among the middle-aged and elderly Chinese population. Further investigations are needed to confirm this association and disclose potential mechanisms.
KW - CA 19-9
KW - Incident diabetes
KW - Prospective study
KW - Risk
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U2 - 10.1007/s00592-016-0937-y
DO - 10.1007/s00592-016-0937-y
M3 - Article
C2 - 27804035
AN - SCOPUS:84994143320
SN - 0940-5429
VL - 54
SP - 201
EP - 208
JO - Acta Diabetologica
JF - Acta Diabetologica
IS - 2
ER -