Abstract
Background:In contrast to the consistent evidence for obesity and colorectal cancer (CRC) risk, the impact of obesity in CRC patients is less clear. In a well-characterised cohort of CRC patients, we prospectively evaluated class I and class II obesity with survival outcomes.Methods:The CRC patients (N=634) were followed from the date of diagnosis until disease progression/first recurrence (progression-free survival (PFS)) or death (overall survival (OS)). Body mass index (BMI) was calculated from reported usual weight prior to diagnosis. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated in models adjusted for clinicopathologic, treatment, and lifestyle factors.Results:Over a median follow-up of 4 years, 208 (33%) patients died and 235 (37%) recurred or progressed. Class II obesity, as compared with either overweight or normal weight, was associated with an increased risk of death (HR and 95% CI: 1.55 (0.97-2.48) and 1.65 (1.02-2.68), respectively), but no clear association was observed with PFS. In analyses restricted to patients who presented as stages I-III, who reported stable weight, or who were aged <50 years, obesity was associated with a significant two- to five-fold increased risk of death.Conclusions:In CRC patients evaluated at a large cancer centre, severely obese patients experienced worse survival outcomes independent of many other factors.
Original language | English (US) |
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Pages (from-to) | 103-109 |
Number of pages | 7 |
Journal | British journal of cancer |
Volume | 114 |
Issue number | 1 |
DOIs | |
State | Published - Jan 12 2016 |
Keywords
- BMI
- colorectal cancer
- lean
- mortality
- obese
- overall survival
- progression
- weight loss
ASJC Scopus subject areas
- Oncology
- Cancer Research
MD Anderson CCSG core facilities
- Clinical Trials Office