@article{50ccae19eb854914b35d74098bd3c73a,
title = "Sex differences in oncogenic mutational processes",
abstract = "Sex differences have been observed in multiple facets of cancer epidemiology, treatment and biology, and in most cancers outside the sex organs. Efforts to link these clinical differences to specific molecular features have focused on somatic mutations within the coding regions of the genome. Here we report a pan-cancer analysis of sex differences in whole genomes of 1983 tumours of 28 subtypes as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium. We both confirm the results of exome studies, and also uncover previously undescribed sex differences. These include sex-biases in coding and non-coding cancer drivers, mutation prevalence and strikingly, in mutational signatures related to underlying mutational processes. These results underline the pervasiveness of molecular sex differences and strengthen the call for increased consideration of sex in molecular cancer research.",
author = "{PCAWG Tumour Subtypes and Clinical Translation} and {PCAWG Consortium} and Li, {Constance H.} and Prokopec, {Stephenie D.} and Sun, {Ren X.} and Fouad Yousif and Nathaniel Schmitz and Fatima Al-Shahrour and Gurnit Atwal and Bailey, {Peter J.} and Biankin, {Andrew V.} and Boutros, {Paul C.} and Campbell, {Peter J.} and Chang, {David K.} and Cooke, {Susanna L.} and Vikram Deshpande and Faltas, {Bishoy M.} and Levi Garraway and Li, {Constance H.} and Rehan Akbani and Akdemir, {Kadir C.} and Kenneth Aldape and Broaddus, {Russell R.} and Campbell, {Peter J.} and Dimple Chakravarty and Ken Chen and Yiwen Chen and Zechen Chong and Bogdan Czerniak and Dunford, {Andrew J.} and Adel El-Naggar and Yu Fan and Futreal, {P. Andrew} and Gershenwald, {Jeffrey E.} and Leng Han and Jason Huse and {von Kalle}, Christof and Savitri Krishnamurthy and Lazar, {Alexander J.} and Jun Li and Han Liang and Peter Lichter and Yiling Lu and Mills, {Gordon B.} and Keunchil Park and Sood, {Anil K.} and Xiaoping Su and Ueno, {Naoto T.} and {Van Loo}, Peter and Linghua Wang and Wenyi Wang and Weinstein, {John N.}",
note = "Publisher Copyright: {\textcopyright} 2020, The Author(s).",
year = "2020",
month = dec,
day = "1",
doi = "10.1038/s41467-020-17359-2",
language = "English (US)",
volume = "11",
journal = "Nature communications",
issn = "2041-1723",
publisher = "Nature Publishing Group",
number = "1",
}