Shear stress-mediated signal transduction

Jun Ichi Abe, Shi Pan, Brooke Krovic, Keigi Fujiwara

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Emerging evidence shows that steady laminar flow is atheroprotective while disturbed flow creates an atheroprone environment in vivo. Chronic inflammation and reactive oxygen species production represent some of the pathogenic features of atherosclerosis formation, and it has become clear that steady laminar flow and disturbed flow or low shear stress have significant roles to modify these atherogenic events via regulating “mechanosignal transduction”. In this chapter, first we will discuss the possible pathological role of mechanosignal transduction in cardiovascular disease. Next the possible role of PECAM-1 as a mechanosensor and its regulatory mechanisms will be reviewed. Third, redox regulation induced by flow and its contribution to endothelial inflammation and apotosis will be summarized. Finally, we will discuss the interplay between cytokine-mediated inflammatory and laminar flow-mediated anti-inflammatory signaling in endothelial cells. The emphasis will be the regulatory mechanism between JNK and ERK5 and posttranslational modification of ERK5 by SUMOylation. We believe that the clarification of these mechanosignaling pathways will lead us to understand the process of atherosclerosis formation in areas exposed to disturbed flow, especially in its initial phase of chronic inflammation.

Original languageEnglish (US)
Title of host publicationHemodynamics and Mechanobiology of Endothelium
PublisherWorld Scientific Publishing Co.
Pages39-68
Number of pages30
ISBN (Electronic)9789814280426
ISBN (Print)9789814280419
DOIs
StatePublished - Jan 1 2010

Fingerprint

Signal transduction
Laminar flow
Shear stress
Signal Transduction
Inflammation
Atherosclerosis
CD31 Antigens
Sumoylation
Endothelial cells
Post Translational Protein Processing
Oxidation-Reduction
Reactive Oxygen Species
Anti-Inflammatory Agents
Cardiovascular Diseases
Endothelial Cells
Cytokines
Oxygen

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Engineering(all)
  • Medicine(all)

Cite this

Abe, J. I., Pan, S., Krovic, B., & Fujiwara, K. (2010). Shear stress-mediated signal transduction. In Hemodynamics and Mechanobiology of Endothelium (pp. 39-68). World Scientific Publishing Co.. https://doi.org/10.1142/9789814280426_0003

Shear stress-mediated signal transduction. / Abe, Jun Ichi; Pan, Shi; Krovic, Brooke; Fujiwara, Keigi.

Hemodynamics and Mechanobiology of Endothelium. World Scientific Publishing Co., 2010. p. 39-68.

Research output: Chapter in Book/Report/Conference proceedingChapter

Abe, JI, Pan, S, Krovic, B & Fujiwara, K 2010, Shear stress-mediated signal transduction. in Hemodynamics and Mechanobiology of Endothelium. World Scientific Publishing Co., pp. 39-68. https://doi.org/10.1142/9789814280426_0003
Abe JI, Pan S, Krovic B, Fujiwara K. Shear stress-mediated signal transduction. In Hemodynamics and Mechanobiology of Endothelium. World Scientific Publishing Co. 2010. p. 39-68 https://doi.org/10.1142/9789814280426_0003
Abe, Jun Ichi ; Pan, Shi ; Krovic, Brooke ; Fujiwara, Keigi. / Shear stress-mediated signal transduction. Hemodynamics and Mechanobiology of Endothelium. World Scientific Publishing Co., 2010. pp. 39-68
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