Short-Term Changes in Cardiac Function in Osteosarcoma Patients Receiving Anthracyclines

Susan C. Gilchrist; Michael Roth; J. Andrew Livingston; Michelle A.T. Hildebrandt; Eugenie S. Kleinerman; Jose Banchs

doi:10.1089/jayao.2018.0141

Short-Term Changes in Cardiac Function in Osteosarcoma Patients Receiving Anthracyclines

Susan C. Gilchrist, Michael Roth, J. Andrew Livingston, Michelle A.T. Hildebrandt, Eugenie S. Kleinerman, Jose Banchs

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Studies of cardiac function in adolescent and young adult survivors have been performed at least a decade after anthracycline exposure, with little knowledge of short-term changes in cardiac function in this age group. To this end, we evaluated cardiac function within a 2-year period among 18 patients who received high-dose anthracyclines for osteosarcoma treatment. At 2 years, there was a significant decline in left ventricular ejection fraction (p = 0.005), with 8 of 18 patients having a >10% reduction. There was a significant change in E-wave velocity (p = 0.04). To our knowledge, this is the first study assessing short-term change in systolic and diastolic function in osteosarcoma patients receiving anthracyclines.

Original language	English (US)
Pages (from-to)	385-386
Number of pages	2
Journal	Journal of adolescent and young adult oncology
Volume	8
Issue number	3
DOIs	https://doi.org/10.1089/jayao.2018.0141
State	Published - Jun 2019

Keywords

adolescent and young adult cancer survivors
anthracyclines
cardiac function
osteosarcoma

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Oncology

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10.1089/jayao.2018.0141

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abstract = "Studies of cardiac function in adolescent and young adult survivors have been performed at least a decade after anthracycline exposure, with little knowledge of short-term changes in cardiac function in this age group. To this end, we evaluated cardiac function within a 2-year period among 18 patients who received high-dose anthracyclines for osteosarcoma treatment. At 2 years, there was a significant decline in left ventricular ejection fraction (p = 0.005), with 8 of 18 patients having a >10% reduction. There was a significant change in E-wave velocity (p = 0.04). To our knowledge, this is the first study assessing short-term change in systolic and diastolic function in osteosarcoma patients receiving anthracyclines.",

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AU - Livingston, J. Andrew

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AU - Kleinerman, Eugenie S.

AU - Banchs, Jose

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Short-Term Changes in Cardiac Function in Osteosarcoma Patients Receiving Anthracyclines

Abstract

Keywords

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