Signaling and ligand interaction of ILT7: Receptor-mediated regulatory mechanisms for plasmacytoid dendritic cells

Wei Cao, Laura Bover

Research output: Contribution to journalReview articlepeer-review

75 Scopus citations

Abstract

Plasmacytoid dendritic cells (pDCs) are specialized dendritic cells (DCs) that produce large amounts of type I interferon (IFN) after Toll-like receptor (TLR) activation. Human pDCs preferentially express immunoglobulin-like transcript 7 (ILT7; LILRA4), which couples with a signaling adapter to activate a prominent immunoreceptor tyrosine-based activation motif (ITAM)-mediated signaling pathway. ILT7 protein directly binds to and can be activated by bone marrow stromal cell antigen 2 (BST2; CD317) protein, the expression of which is found on cells pre-exposed to IFN or on the surface of human cancer cells. The interaction between ILT7 and BST2 functions to assure an appropriate TLR response by pDCs during viral infection and likely participates in pDC-tumor crosstalk. Two opposing modes of receptor-mediated regulatory mechanisms work jointly to fine tune the innate immunity of pDCs.

Original languageEnglish (US)
Pages (from-to)163-176
Number of pages14
JournalImmunological Reviews
Volume234
Issue number1
DOIs
StatePublished - Mar 2010

Keywords

  • BST2
  • Dendritic cell receptors
  • Dendritic cells
  • ILT7
  • Plasmacytoid dendritic cells
  • Receptor signal

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

MD Anderson CCSG core facilities

  • Monoclonal Antibody Facility

Fingerprint

Dive into the research topics of 'Signaling and ligand interaction of ILT7: Receptor-mediated regulatory mechanisms for plasmacytoid dendritic cells'. Together they form a unique fingerprint.

Cite this