Abstract
MiRNAs are important regulatory elements for gene expression that are involved in diverse physiologic and pathologic processes. Canonical miRNA biogenesis consists of a two-step processing, from primary transcripts (pri-miRNA) to precursor miRNAs (pre-miRNA) mediated by Drosha in the nucleus and from pre-miRNAs to mature miRNAs mediated by Dicer in the cytoplasm. Various routes of miRNA maturation that are tightly regulated by signaling cascades and specific to an individual or a subclass of miRNAs have been recently identified. Here, we review the current findings in signaling-mediated miRNA processing as well as their potential clinical relevance in cancer.
Original language | English (US) |
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Pages (from-to) | 783-791 |
Number of pages | 9 |
Journal | Cancer Research |
Volume | 75 |
Issue number | 5 |
DOIs | |
State | Published - Mar 1 2015 |
ASJC Scopus subject areas
- Oncology
- Cancer Research