Signet ring cell mixed histology may show more aggressive behavior than other histologies in early gastric cancer

Cheal Wung Huh, Da Hyun Jung, Jie Hyun Kim, Yong Chan Lee, Hyunki Kim, Hoguen Kim, Sun Och Yoon, Young Hoon Youn, Hyojin Park, Sang In Lee, Seung Ho Choi, Jae Ho Cheong, Sung Hoon Noh

    Research output: Contribution to journalArticle

    40 Scopus citations

    Abstract

    Background: Signet ring cell carcinoma (SRC) of the stomach is known to have different microscopic and biologic characteristics compared to non-SRC. The pathologic report has documented partly SRC component with main histologies. However, the clinical significance of SRC mixture has not been reported. Aim was to investigate clinicopathologic features of mixed-SRC histology in early gastric cancer (EGC). Methods: Two thousand two hundred eight patients were diagnosed with EGC and underwent surgery. The patients were divided into three groups such as adenocarcinoma with partly SRC (mixed-SRC group), only adenocarcinoma (adenocarcinoma group), and SRC (SRC group). Clinicopathologic characteristics were compared. Results: The SRC group was more associated with younger age, female, mid-body, mucosa-confined, depressed type, lower lymph node metastasis (LNM), lower lymphovascular invasion, and better survival rate than adenocarcinoma group. The mixed-SRC group was more associated with younger age, female, upper-body, and depressed type than adenocarcinoma group, similar to SRC group. However, the mixed-SRC group showed more submucosal invasion, larger size, and higher LNM than other groups. The mixed-SRC component was one of the independent risk factors of LNM. Conclusions: Mixed-SRC histology in EGC showed more aggressive behavior than other histologies. Clinical considerations of mixed-SRC histology may be helpful to decide on a specific cancer treatment.

    Original languageEnglish (US)
    Pages (from-to)124-129
    Number of pages6
    JournalJournal of surgical oncology
    Volume107
    Issue number2
    DOIs
    StatePublished - Feb 1 2013

    Keywords

    • biologic characteristics
    • early gastric cancer
    • signet ring cell carcinoma

    ASJC Scopus subject areas

    • Surgery
    • Oncology

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  • Cite this

    Huh, C. W., Jung, D. H., Kim, J. H., Lee, Y. C., Kim, H., Kim, H., Yoon, S. O., Youn, Y. H., Park, H., Lee, S. I., Choi, S. H., Cheong, J. H., & Noh, S. H. (2013). Signet ring cell mixed histology may show more aggressive behavior than other histologies in early gastric cancer. Journal of surgical oncology, 107(2), 124-129. https://doi.org/10.1002/jso.23261