Simboolnet-A cytoscape plugin for dynamic simulation of signaling networks

Jie Zheng; David Zhang; Pawel F. Przytycki; Rafal Zielinski; Jacek Capala; Teresa M. Przytycka

doi:10.1093/bioinformatics/btp617

Simboolnet-A cytoscape plugin for dynamic simulation of signaling networks

Jie Zheng, David Zhang, Pawel F. Przytycki, Rafal Zielinski, Jacek Capala, Teresa M. Przytycka

Research output: Contribution to journal › Comment/debate › peer-review

46 Scopus citations

Abstract

SimBoolNet is an open source Cytoscape plugin that simulates the dynamics of signaling transduction using Boolean networks. Given a user-specified level of stimulation to signal receptors, SimBoolNet simulates the response of downstream molecules and visualizes with animation and records the dynamic changes of the network. It can be used to generate hypotheses and facilitate experimental studies about causal relations and crosstalk among cellular signaling pathways.

Original language	English (US)
Pages (from-to)	141-142
Number of pages	2
Journal	Bioinformatics
Volume	26
Issue number	1
DOIs	https://doi.org/10.1093/bioinformatics/btp617
State	Published - Nov 3 2009
Externally published	Yes

ASJC Scopus subject areas

Statistics and Probability
Biochemistry
Molecular Biology
Computer Science Applications
Computational Theory and Mathematics
Computational Mathematics

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10.1093/bioinformatics/btp617

Cite this

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AU - Przytycki, Pawel F.

AU - Zielinski, Rafal

AU - Capala, Jacek

AU - Przytycka, Teresa M.

PY - 2009/11/3

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AB - SimBoolNet is an open source Cytoscape plugin that simulates the dynamics of signaling transduction using Boolean networks. Given a user-specified level of stimulation to signal receptors, SimBoolNet simulates the response of downstream molecules and visualizes with animation and records the dynamic changes of the network. It can be used to generate hypotheses and facilitate experimental studies about causal relations and crosstalk among cellular signaling pathways.

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Simboolnet-A cytoscape plugin for dynamic simulation of signaling networks

Abstract

ASJC Scopus subject areas

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