Simultaneous infection with enterobacteriaceae and pseudomonas aeruginosa harboring multiple carbapenemases in a returning traveler colonized with candida auris

Ayesha Khan; William C. Shropshire; Blake Hanson; An Q. Dinh; Audrey Wanger; Luis Ostrosky-Zeichner; Cesar A. Arias; William R. Miller

doi:10.1128/AAC.01466-19

Simultaneous infection with enterobacteriaceae and pseudomonas aeruginosa harboring multiple carbapenemases in a returning traveler colonized with candida auris

Ayesha Khan
, William C. Shropshire
, Blake Hanson
, An Q. Dinh
, Audrey Wanger
, Luis Ostrosky-Zeichner
, Cesar A. Arias
, William R. Miller

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

We report our clinical experience treating a critically ill patient with polymicrobial infections due to multidrug-resistant Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa in a 56-year-old woman who received health care in India and was also colonized by Candida auris. A precision medicine approach using whole-genome sequencing revealed a multiplicity of mobile elements associated with NDM-1, NDM-5, and OXA-181 and, supplemented with susceptibility testing, guided the selection of rational antimicrobial therapy.

Original language	English (US)
Article number	e01466
Journal	Antimicrobial agents and chemotherapy
Volume	64
Issue number	2
DOIs	https://doi.org/10.1128/AAC.01466-19
State	Published - Jan 27 2020
Externally published	Yes

Keywords

Candida auris
Carbapenemase
Enterobacteriaceae
NDM
Polymicrobial infection
Pseudomonas aeruginosa

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

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10.1128/AAC.01466-19

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Khan, A., Shropshire, W. C., Hanson, B., Dinh, A. Q., Wanger, A., Ostrosky-Zeichner, L., Arias, C. A., & Miller, W. R. (2020). Simultaneous infection with enterobacteriaceae and pseudomonas aeruginosa harboring multiple carbapenemases in a returning traveler colonized with candida auris. Antimicrobial agents and chemotherapy, 64(2), Article e01466. https://doi.org/10.1128/AAC.01466-19

Khan, A, Shropshire, WC, Hanson, B, Dinh, AQ, Wanger, A, Ostrosky-Zeichner, L, Arias, CA & Miller, WR 2020, 'Simultaneous infection with enterobacteriaceae and pseudomonas aeruginosa harboring multiple carbapenemases in a returning traveler colonized with candida auris', Antimicrobial agents and chemotherapy, vol. 64, no. 2, e01466. https://doi.org/10.1128/AAC.01466-19

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AU - Khan, Ayesha

AU - Shropshire, William C.

AU - Hanson, Blake

AU - Dinh, An Q.

AU - Wanger, Audrey

AU - Ostrosky-Zeichner, Luis

AU - Arias, Cesar A.

AU - Miller, William R.

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AB - We report our clinical experience treating a critically ill patient with polymicrobial infections due to multidrug-resistant Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa in a 56-year-old woman who received health care in India and was also colonized by Candida auris. A precision medicine approach using whole-genome sequencing revealed a multiplicity of mobile elements associated with NDM-1, NDM-5, and OXA-181 and, supplemented with susceptibility testing, guided the selection of rational antimicrobial therapy.

KW - Candida auris

KW - Carbapenemase

KW - Enterobacteriaceae

KW - NDM

KW - Polymicrobial infection

KW - Pseudomonas aeruginosa

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Simultaneous infection with enterobacteriaceae and pseudomonas aeruginosa harboring multiple carbapenemases in a returning traveler colonized with candida auris

Abstract

Keywords

ASJC Scopus subject areas

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