Sinonasal adenoid cystic carcinoma: Treatment outcomes and association with human papillomavirus

Eric D. Miller; Dukagjin M. Blakaj; Benjamin J. Swanson; Weihong Xiao; Maura L. Gillison; Lai Wei; Aashish D. Bhatt; Virginia M. Diavolitsis; Jessica L. Wobb; Stephen Y. Kang; Ricardo L. Carrau; John C. Grecula

doi:10.1002/hed.24778

Sinonasal adenoid cystic carcinoma: Treatment outcomes and association with human papillomavirus

Eric D. Miller, Dukagjin M. Blakaj, Benjamin J. Swanson, Weihong Xiao, Maura L. Gillison, Lai Wei, Aashish D. Bhatt, Virginia M. Diavolitsis, Jessica L. Wobb, Stephen Y. Kang, Ricardo L. Carrau, John C. Grecula

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Background: The purpose of this study was to review long-term outcomes of sinonasal adenoid cystic carcinoma (ACC) and to clarify its association with human papillomavirus (HPV). Methods: The medical records of 23 patients with sinonasal ACC treated with primary surgical resection between 1998 and 2013 were reviewed. Tissue specimens were available for 17 patients. The p16 testing was performed using immunohistochemistry (IHC), and HPV infection was determined using quantitative polymerase chain reaction (PCR) with primers targeting the E6/E7 region. Results: Two of the 17 samples showed strong and diffuse p16 staining, whereas the remaining 15 cases showed p16-positivity isolated to the luminal cells. Only one of the p16-positive cases was positive for HPV. The 5-year local failure, disease-free survival (DFS), and overall survival (OS) were 51%, 52%, and 62%, respectively. Conclusion: Local failures are common with advanced sinonasal ACC, and the association of HPV with true sinonasal ACC is low.

Original language	English (US)
Pages (from-to)	1405-1411
Number of pages	7
Journal	Head and Neck
Volume	39
Issue number	7
DOIs	https://doi.org/10.1002/hed.24778
State	Published - Jul 2017
Externally published	Yes

Keywords

adenoid cystic carcinoma
human papillomavirus
p16
paranasal sinus neoplasms
radiotherapy

ASJC Scopus subject areas

Otorhinolaryngology

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10.1002/hed.24778

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title = "Sinonasal adenoid cystic carcinoma: Treatment outcomes and association with human papillomavirus",

abstract = "Background: The purpose of this study was to review long-term outcomes of sinonasal adenoid cystic carcinoma (ACC) and to clarify its association with human papillomavirus (HPV). Methods: The medical records of 23 patients with sinonasal ACC treated with primary surgical resection between 1998 and 2013 were reviewed. Tissue specimens were available for 17 patients. The p16 testing was performed using immunohistochemistry (IHC), and HPV infection was determined using quantitative polymerase chain reaction (PCR) with primers targeting the E6/E7 region. Results: Two of the 17 samples showed strong and diffuse p16 staining, whereas the remaining 15 cases showed p16-positivity isolated to the luminal cells. Only one of the p16-positive cases was positive for HPV. The 5-year local failure, disease-free survival (DFS), and overall survival (OS) were 51%, 52%, and 62%, respectively. Conclusion: Local failures are common with advanced sinonasal ACC, and the association of HPV with true sinonasal ACC is low.",

keywords = "adenoid cystic carcinoma, human papillomavirus, p16, paranasal sinus neoplasms, radiotherapy",

author = "Miller, {Eric D.} and Blakaj, {Dukagjin M.} and Swanson, {Benjamin J.} and Weihong Xiao and Gillison, {Maura L.} and Lai Wei and Bhatt, {Aashish D.} and Diavolitsis, {Virginia M.} and Wobb, {Jessica L.} and Kang, {Stephen Y.} and Carrau, {Ricardo L.} and Grecula, {John C.}",

note = "Publisher Copyright: {\textcopyright} 2017 Wiley Periodicals, Inc.",

year = "2017",

month = jul,

doi = "10.1002/hed.24778",

language = "English (US)",

volume = "39",

pages = "1405--1411",

journal = "Head and Neck",

issn = "1043-3074",

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TY - JOUR

T1 - Sinonasal adenoid cystic carcinoma

T2 - Treatment outcomes and association with human papillomavirus

AU - Miller, Eric D.

AU - Blakaj, Dukagjin M.

AU - Swanson, Benjamin J.

AU - Xiao, Weihong

AU - Gillison, Maura L.

AU - Wei, Lai

AU - Bhatt, Aashish D.

AU - Diavolitsis, Virginia M.

AU - Wobb, Jessica L.

AU - Kang, Stephen Y.

AU - Carrau, Ricardo L.

AU - Grecula, John C.

PY - 2017/7

Y1 - 2017/7

N2 - Background: The purpose of this study was to review long-term outcomes of sinonasal adenoid cystic carcinoma (ACC) and to clarify its association with human papillomavirus (HPV). Methods: The medical records of 23 patients with sinonasal ACC treated with primary surgical resection between 1998 and 2013 were reviewed. Tissue specimens were available for 17 patients. The p16 testing was performed using immunohistochemistry (IHC), and HPV infection was determined using quantitative polymerase chain reaction (PCR) with primers targeting the E6/E7 region. Results: Two of the 17 samples showed strong and diffuse p16 staining, whereas the remaining 15 cases showed p16-positivity isolated to the luminal cells. Only one of the p16-positive cases was positive for HPV. The 5-year local failure, disease-free survival (DFS), and overall survival (OS) were 51%, 52%, and 62%, respectively. Conclusion: Local failures are common with advanced sinonasal ACC, and the association of HPV with true sinonasal ACC is low.

AB - Background: The purpose of this study was to review long-term outcomes of sinonasal adenoid cystic carcinoma (ACC) and to clarify its association with human papillomavirus (HPV). Methods: The medical records of 23 patients with sinonasal ACC treated with primary surgical resection between 1998 and 2013 were reviewed. Tissue specimens were available for 17 patients. The p16 testing was performed using immunohistochemistry (IHC), and HPV infection was determined using quantitative polymerase chain reaction (PCR) with primers targeting the E6/E7 region. Results: Two of the 17 samples showed strong and diffuse p16 staining, whereas the remaining 15 cases showed p16-positivity isolated to the luminal cells. Only one of the p16-positive cases was positive for HPV. The 5-year local failure, disease-free survival (DFS), and overall survival (OS) were 51%, 52%, and 62%, respectively. Conclusion: Local failures are common with advanced sinonasal ACC, and the association of HPV with true sinonasal ACC is low.

KW - adenoid cystic carcinoma

KW - human papillomavirus

KW - p16

KW - paranasal sinus neoplasms

KW - radiotherapy

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Sinonasal adenoid cystic carcinoma: Treatment outcomes and association with human papillomavirus

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