SIRT1 Regulates Lysosome Function and Exosome Secretion

Research output: Contribution to journalShort surveypeer-review

24 Scopus citations

Abstract

The NAD + −dependent deacetylase Sirtuin 1 (SIRT1) regulates cell metabolism, proliferation, and DNA repair and acts as a tumor suppressor in breast cancer. In this issue of Developmental Cell, Latifkar et al. show that SIRT1 controls lysosomal acidification and its loss enhances the secretion of pro-tumorigenic exosomes for breast cancer invasion. The NAD + −dependent deacetylase Sirtuin 1 (SIRT1) regulates cell metabolism, proliferation, and DNA repair and acts as a tumor suppressor in breast cancer. In this issue of Developmental Cell, Latifkar et al. show that SIRT1 controls lysosomal acidification and its loss enhances the secretion of pro-tumorigenic exosomes for breast cancer invasion.

Original languageEnglish (US)
Pages (from-to)302-303
Number of pages2
JournalDevelopmental cell
Volume49
Issue number3
DOIs
StatePublished - May 6 2019

ASJC Scopus subject areas

  • Molecular Biology
  • General Biochemistry, Genetics and Molecular Biology
  • Developmental Biology
  • Cell Biology

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