TY - JOUR
T1 - SIRT1 Regulates Lysosome Function and Exosome Secretion
AU - McAndrews, Kathleen M.
AU - LeBleu, Valerie
AU - Kalluri, Raghu
N1 - Funding Information:
MD Anderson Cancer Center and R.K. hold patents in the area of exosome biology and are licensed to Codiak Biosciences Inc. MD Anderson Cancer Center and R.K. are stock equity holders in Codiak Biosciences Inc. R.K. is a consultant and a scientific advisor and receives research support from Codiak Biosciences Inc. R.K. previously served as a member of the board of directors of Codiak Biosciences. V.S.L. is a paid consultant for Codiak Biosciences.
Publisher Copyright:
© 2019 Elsevier Inc.
PY - 2019/5/6
Y1 - 2019/5/6
N2 - The NAD + −dependent deacetylase Sirtuin 1 (SIRT1) regulates cell metabolism, proliferation, and DNA repair and acts as a tumor suppressor in breast cancer. In this issue of Developmental Cell, Latifkar et al. show that SIRT1 controls lysosomal acidification and its loss enhances the secretion of pro-tumorigenic exosomes for breast cancer invasion. The NAD + −dependent deacetylase Sirtuin 1 (SIRT1) regulates cell metabolism, proliferation, and DNA repair and acts as a tumor suppressor in breast cancer. In this issue of Developmental Cell, Latifkar et al. show that SIRT1 controls lysosomal acidification and its loss enhances the secretion of pro-tumorigenic exosomes for breast cancer invasion.
AB - The NAD + −dependent deacetylase Sirtuin 1 (SIRT1) regulates cell metabolism, proliferation, and DNA repair and acts as a tumor suppressor in breast cancer. In this issue of Developmental Cell, Latifkar et al. show that SIRT1 controls lysosomal acidification and its loss enhances the secretion of pro-tumorigenic exosomes for breast cancer invasion. The NAD + −dependent deacetylase Sirtuin 1 (SIRT1) regulates cell metabolism, proliferation, and DNA repair and acts as a tumor suppressor in breast cancer. In this issue of Developmental Cell, Latifkar et al. show that SIRT1 controls lysosomal acidification and its loss enhances the secretion of pro-tumorigenic exosomes for breast cancer invasion.
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U2 - 10.1016/j.devcel.2019.04.024
DO - 10.1016/j.devcel.2019.04.024
M3 - Short survey
C2 - 31063745
AN - SCOPUS:85064546705
SN - 1534-5807
VL - 49
SP - 302
EP - 303
JO - Developmental cell
JF - Developmental cell
IS - 3
ER -