Skin Barrier Repair in Eczema: A Review of Current Understanding of Pathophysiology and Treatment

Omar Pacha; Brittany L. Sambrano; Adelaide A. Hebert

doi:10.1007/s13671-012-0018-6

Skin Barrier Repair in Eczema: A Review of Current Understanding of Pathophysiology and Treatment

Omar Pacha, Brittany L. Sambrano, Adelaide A. Hebert

Dermatology

Research output: Contribution to journal › Review article › peer-review

3 Scopus citations

Abstract

Atopic dermatitis is an exceedingly common condition that is often difficult to treat. In this review, the pathophysiology and recent developments are discussed to understand how to better treat atopic dermatitis through the improved understanding of the breakdown of the skin barrier in atopic patients. The available treatments that address these barrier defects are discussed in the light of recent publications.

Original language	English (US)
Pages (from-to)	115-122
Number of pages	8
Journal	Current Dermatology Reports
Volume	1
Issue number	3
DOIs	https://doi.org/10.1007/s13671-012-0018-6
State	Published - Sep 2012

Keywords

Atopic dermatitis
Betamethasone
Calcineurin inhibitors
Ceramides
Corticosteroids
Dermatopharmacology
Eczema
Filaggrin
IL-31
Ichthyosis vulgaris
Interleukin-31
Pathophysiology
Pimecrolimus
Skin barrier repair
Therapy

ASJC Scopus subject areas

Dermatology

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10.1007/s13671-012-0018-6

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title = "Skin Barrier Repair in Eczema: A Review of Current Understanding of Pathophysiology and Treatment",

abstract = "Atopic dermatitis is an exceedingly common condition that is often difficult to treat. In this review, the pathophysiology and recent developments are discussed to understand how to better treat atopic dermatitis through the improved understanding of the breakdown of the skin barrier in atopic patients. The available treatments that address these barrier defects are discussed in the light of recent publications.",

keywords = "Atopic dermatitis, Betamethasone, Calcineurin inhibitors, Ceramides, Corticosteroids, Dermatopharmacology, Eczema, Filaggrin, IL-31, Ichthyosis vulgaris, Interleukin-31, Pathophysiology, Pimecrolimus, Skin barrier repair, Therapy",

author = "Omar Pacha and Sambrano, {Brittany L.} and Hebert, {Adelaide A.}",

year = "2012",

month = sep,

doi = "10.1007/s13671-012-0018-6",

language = "English (US)",

volume = "1",

pages = "115--122",

journal = "Current Dermatology Reports",

issn = "2162-4933",

publisher = "Springer US",

number = "3",

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TY - JOUR

T1 - Skin Barrier Repair in Eczema

T2 - A Review of Current Understanding of Pathophysiology and Treatment

AU - Pacha, Omar

AU - Sambrano, Brittany L.

AU - Hebert, Adelaide A.

PY - 2012/9

Y1 - 2012/9

N2 - Atopic dermatitis is an exceedingly common condition that is often difficult to treat. In this review, the pathophysiology and recent developments are discussed to understand how to better treat atopic dermatitis through the improved understanding of the breakdown of the skin barrier in atopic patients. The available treatments that address these barrier defects are discussed in the light of recent publications.

AB - Atopic dermatitis is an exceedingly common condition that is often difficult to treat. In this review, the pathophysiology and recent developments are discussed to understand how to better treat atopic dermatitis through the improved understanding of the breakdown of the skin barrier in atopic patients. The available treatments that address these barrier defects are discussed in the light of recent publications.

KW - Atopic dermatitis

KW - Betamethasone

KW - Calcineurin inhibitors

KW - Ceramides

KW - Corticosteroids

KW - Dermatopharmacology

KW - Eczema

KW - Filaggrin

KW - IL-31

KW - Ichthyosis vulgaris

KW - Interleukin-31

KW - Pathophysiology

KW - Pimecrolimus

KW - Skin barrier repair

KW - Therapy

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DO - 10.1007/s13671-012-0018-6

M3 - Review article

AN - SCOPUS:85069328636

SN - 2162-4933

VL - 1

SP - 115

EP - 122

JO - Current Dermatology Reports

JF - Current Dermatology Reports

IS - 3

ER -

Skin Barrier Repair in Eczema: A Review of Current Understanding of Pathophysiology and Treatment

Abstract

Keywords

ASJC Scopus subject areas

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