TY - JOUR
T1 - Sleep duration and type 2 diabetes risk
T2 - A prospective study in a population-based Mexican American cohort
AU - Wu, Ivan HC
AU - Heredia, Natalia
AU - Dong, Qiong
AU - McNeill, Lorna H.
AU - Balachandran, Diwakar D.
AU - Lu, Qian
AU - Chang, Shine
N1 - Funding Information:
The Mexican American Cohort receives funds collected pursuant to the Comprehensive Tobacco Settlement of 1998 and appropriated by the 76th legislature to The University of Texas MD Anderson Cancer Center, also, from the Caroline W. Law Fund for Cancer Prevention, and the Dan Duncan Family Institute for Risk Assessment and Cancer Prevention. There are no financial disclosures from any authors. Its content are solely the responsibility of the authors and do not necessarily represent the official views of the project supporters.
Funding Information:
Ivan H.C. Wu, PhD and the research activities were supported in part by the Cancer Prevention and Research Institute of Texas (CPRIT) award ID RP170259 , Shine Chang, PhD and Sanjay Shete, PhD, Principal Investigators), the MD Anderson's Cancer Center support grant ( CA016672 , Peter Pisters, Principal Investigator) funded by the National Cancer Institute , and the UHAND Partnership funded by the National Cancer Institute ( P20CA221696 and P20CA221697 ).
Publisher Copyright:
© 2021 National Sleep Foundation
PY - 2021/4
Y1 - 2021/4
N2 - Study Objectives: The primary aim of the study was to estimate the effect of sleep duration on prospective type 2 diabetes (T2D) risk across demographic characteristics and follow-up periods, and test body mass index (BMI) as a mediator and moderator. Methods: Data included adults (Mage = 39.0 ± 12.7 years) born in the United States or Mexico recruited from 2001 to 2012 in a Mexican American cohort study conducted in Houston, TX (n = 15,779). Participants completed self-reported questionnaires at baseline related to health, health behaviors (sleep duration, physical activity, smoking, drinking), and sociocultural factors and were followed up annually. Results: Cox proportional hazard models estimated hazard ratios (HR) for the effect of sleep duration on T2D diagnosis at follow-up. Of the participants, 10.3% were diagnosed with T2D. Self-reported ≤5 hours of sleep, compared to 7-8 hours, at baseline predicted greater risk for T2D (HR = 1.32, P = .001), yet was no longer significant after adjusting for sociodemographic characteristics and BMI. Notably, those with BMI <25 kg/m2 reporting ≤5 hours of sleep were at significant risk for T2D at 3 (HR = 4.13, P = .024) and 5-year follow-up (HR = 3.73, P = .008) compared to 7-8 hours. Obesity status accounted for 31.6% and 27.3% of the variance in the association between ≤5 and 6 hours of sleep and increased T2D risk, respectively. Conclusions: Results highlighted the mediating and moderating role of BMI, and its effect on T2D risk at earlier follow-up among those without obesity. T2D prevention and control for Mexican American adults should consider the role of chronic sleep loss.
AB - Study Objectives: The primary aim of the study was to estimate the effect of sleep duration on prospective type 2 diabetes (T2D) risk across demographic characteristics and follow-up periods, and test body mass index (BMI) as a mediator and moderator. Methods: Data included adults (Mage = 39.0 ± 12.7 years) born in the United States or Mexico recruited from 2001 to 2012 in a Mexican American cohort study conducted in Houston, TX (n = 15,779). Participants completed self-reported questionnaires at baseline related to health, health behaviors (sleep duration, physical activity, smoking, drinking), and sociocultural factors and were followed up annually. Results: Cox proportional hazard models estimated hazard ratios (HR) for the effect of sleep duration on T2D diagnosis at follow-up. Of the participants, 10.3% were diagnosed with T2D. Self-reported ≤5 hours of sleep, compared to 7-8 hours, at baseline predicted greater risk for T2D (HR = 1.32, P = .001), yet was no longer significant after adjusting for sociodemographic characteristics and BMI. Notably, those with BMI <25 kg/m2 reporting ≤5 hours of sleep were at significant risk for T2D at 3 (HR = 4.13, P = .024) and 5-year follow-up (HR = 3.73, P = .008) compared to 7-8 hours. Obesity status accounted for 31.6% and 27.3% of the variance in the association between ≤5 and 6 hours of sleep and increased T2D risk, respectively. Conclusions: Results highlighted the mediating and moderating role of BMI, and its effect on T2D risk at earlier follow-up among those without obesity. T2D prevention and control for Mexican American adults should consider the role of chronic sleep loss.
KW - Health behaviors
KW - Mexican Americans
KW - Obesity
KW - Sleep
KW - Type 2 diabetes risk
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U2 - 10.1016/j.sleh.2020.12.003
DO - 10.1016/j.sleh.2020.12.003
M3 - Article
C2 - 33582048
AN - SCOPUS:85101825196
SN - 2352-7218
VL - 7
SP - 168
EP - 176
JO - Sleep Health
JF - Sleep Health
IS - 2
ER -