TY - JOUR
T1 - Solitary fibrous tumor
T2 - A clinicopathological study of 110 cases and proposed risk assessment model
AU - Demicco, Elizabeth G.
AU - Park, Min S.
AU - Araujo, Dejka M.
AU - Fox, Patricia S.
AU - Bassett, Roland L.
AU - Pollock, Raphael E.
AU - Lazar, Alexander J.
AU - Wang, Wei Lien
N1 - Funding Information:
We would like to acknowledge Kim Vu for her expert assistance in the figures. This work was supported in part by the Cancer Center Support Grant (NCI Grant P30 CA016672) (PSF, RLB), The University of Texas M.D. Anderson Cancer Center funds for research (W-LW, AJL), and the Physician-Scientist Program (AJL), and the WWWW Foundation (QuadW) (MSP).
PY - 2012/9
Y1 - 2012/9
N2 - Solitary fibrous tumor represents a spectrum of mesenchymal tumors, encompassing tumors previously termed hemangiopericytoma, which are classified as having intermediate biological potential (rarely metastasizing) in the 2002 World Health Organization classification scheme. Few series have reported on clinicopathological predictors with outcome data and formal statistical analysis in a large series of primary tumors as a single unified entity. Institutional pathology records were reviewed to identify primary solitary fibrous tumor cases, and histological sections and clinical records reviewed for canonical prognostic indicators, including patient age, tumor size, mitotic index, tumor cellularity, nuclear pleomorphism, and tumor necrosis. Patients (n103) with resected primary solitary fibrous tumor were identified (excluding meningeal tumors). The most common sites of occurrence were abdomen and pleura; these tumors were larger than those occurring in the extremities, head and neck or trunk, but did not demonstrate significant outcome differences. Overall 5-and 10-year metastasis-free rates were 74 and 55%, respectively, while 5-and 10-year disease-specific survival rates were 89 and 73%. Patient age, tumor size, and mitotic index predicted both time to metastasis and disease-specific mortality, while necrosis predicted metastasis only. A risk stratification model based on age, size, and mitotic index clearly delineated patients at high risk for poor outcomes. While small tumors with low mitotic rates are highly unlikely to metastasize, large tumors 15 cm, which occur in patients 55 years, with mitotic figures 4/10 high-power fields require close follow-up and have a high risk of both metastasis and death.
AB - Solitary fibrous tumor represents a spectrum of mesenchymal tumors, encompassing tumors previously termed hemangiopericytoma, which are classified as having intermediate biological potential (rarely metastasizing) in the 2002 World Health Organization classification scheme. Few series have reported on clinicopathological predictors with outcome data and formal statistical analysis in a large series of primary tumors as a single unified entity. Institutional pathology records were reviewed to identify primary solitary fibrous tumor cases, and histological sections and clinical records reviewed for canonical prognostic indicators, including patient age, tumor size, mitotic index, tumor cellularity, nuclear pleomorphism, and tumor necrosis. Patients (n103) with resected primary solitary fibrous tumor were identified (excluding meningeal tumors). The most common sites of occurrence were abdomen and pleura; these tumors were larger than those occurring in the extremities, head and neck or trunk, but did not demonstrate significant outcome differences. Overall 5-and 10-year metastasis-free rates were 74 and 55%, respectively, while 5-and 10-year disease-specific survival rates were 89 and 73%. Patient age, tumor size, and mitotic index predicted both time to metastasis and disease-specific mortality, while necrosis predicted metastasis only. A risk stratification model based on age, size, and mitotic index clearly delineated patients at high risk for poor outcomes. While small tumors with low mitotic rates are highly unlikely to metastasize, large tumors 15 cm, which occur in patients 55 years, with mitotic figures 4/10 high-power fields require close follow-up and have a high risk of both metastasis and death.
KW - clinicopathological factors
KW - hemangiopericytoma
KW - metastasis
KW - risk assessment
KW - solitary fibrous tumor
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U2 - 10.1038/modpathol.2012.83
DO - 10.1038/modpathol.2012.83
M3 - Review article
C2 - 22575866
AN - SCOPUS:84865726314
SN - 0893-3952
VL - 25
SP - 1298
EP - 1306
JO - Modern Pathology
JF - Modern Pathology
IS - 9
ER -