Soluble tumor necrosis factor (sTNF) receptors: A possible prognostic marker for bone marrow transplantation-related complications

R. Or, A. Galinkovich, Arnon Nagler, Z. Weisman, E. Naparstek, L. Weiss, T. Hahn

    Research output: Contribution to journalArticle

    21 Scopus citations

    Abstract

    involvement of tumor necrosis factor (TNF) in bone marrow transplantation (BMT)-associated complications has been documented. Biological response to TNF requires interaction with specific cell membrane receptors. Extracellular domains of these receptors are released into body fluids as soluble molecules, and participate in the bioactivity of TNF. Serum levels of p55 and p75 soluble tumor necrosis factor receptors (sTNFR) were determined in 34 patients with different diseases who underwent BMT. Sequential studies initiated 10 days before BMT and continued up to 110 days post-transplantation showed that p55 and p75 sTNFR levels were elevated significantly in patients who subsequently developed major transplant-related complications (TRC). Moreover, both sTNFR levels were increased 2- to 3-fold over control values during post-BMT febrile periods in those patients who at a later stage suffered major TRC. These results indicate that the serum level of sTNFR may be used as a prognostic marker for major TRC in BMT.

    Original languageEnglish (US)
    Pages (from-to)243-250
    Number of pages8
    JournalCytokines and Molecular Therapy
    Volume2
    Issue number4
    StatePublished - Dec 1 1996

    Keywords

    • Bone marrow transplantation
    • Soluble tumor necrosis factor receptors

    ASJC Scopus subject areas

    • Immunology and Allergy
    • Pharmacology

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    Or, R., Galinkovich, A., Nagler, A., Weisman, Z., Naparstek, E., Weiss, L., & Hahn, T. (1996). Soluble tumor necrosis factor (sTNF) receptors: A possible prognostic marker for bone marrow transplantation-related complications. Cytokines and Molecular Therapy, 2(4), 243-250.