TY - JOUR
T1 - Spatiotemporally controlled nano-sized third harmonic generation agents
AU - Nevozhay, Dmitry
AU - Weiger, Michael
AU - Friedl, Peter
AU - Sokolov, Konstantin V.
N1 - Funding Information:
National Institutes of Health (NIH)/National Cancer Institute (NCI) (R21 CA231561, P30 CA016672); Genitourinary Cancers Program of the CCSG shared resources at The University of Texas MD Anderson Cancer Center; Prostate Cancer Moonshot Program at The University of Texas MD Anderson Cancer Center; the European Research Council (617430-DEEPINSIGHT); the NIH (U54 CA210184-01); and the Cancer Genomics Center (CGC.nl).
Publisher Copyright:
© 2019 Optical Society of America under the terms of the OSA Open Access Publishing Agreement.
PY - 2019/7
Y1 - 2019/7
N2 - Here, we present a new class of third harmonic generation (THG) imaging probes that can be activated with precise spatiotemporal control using non-linear excitation. These probes consist of lipid-coated perfluorocarbon nanodroplets with embedded visible chromophores. The droplets undergo phase transition from liquid to gas upon heating mediated by two-photon absorption of NIR light by the embedded dyes. Resulting microbubbles provide a sharp, local refractive index mismatch, which makes an excellent source of THG signal. Potential applications of these probes include activatable THG agents for biological imaging and “on-demand” delivery of various compounds under THG monitoring.
AB - Here, we present a new class of third harmonic generation (THG) imaging probes that can be activated with precise spatiotemporal control using non-linear excitation. These probes consist of lipid-coated perfluorocarbon nanodroplets with embedded visible chromophores. The droplets undergo phase transition from liquid to gas upon heating mediated by two-photon absorption of NIR light by the embedded dyes. Resulting microbubbles provide a sharp, local refractive index mismatch, which makes an excellent source of THG signal. Potential applications of these probes include activatable THG agents for biological imaging and “on-demand” delivery of various compounds under THG monitoring.
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U2 - 10.1364/BOE.10.003301
DO - 10.1364/BOE.10.003301
M3 - Article
C2 - 31360600
AN - SCOPUS:85070682274
SN - 2156-7085
VL - 10
SP - 3301
EP - 3316
JO - Biomedical Optics Express
JF - Biomedical Optics Express
IS - 7
M1 - 364132
ER -